2013 Fiscal Year Final Research Report
Role of Keap1-Nrf2 system in skin wound healing process
| Project/Area Number |
23390407
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YANAGAWA Toru 筑波大学, 医学医療系, 准教授 (10312852)
WARABI Eiji 筑波大学, 医学医療系, 講師 (70396612)
SHODA Junichi 筑波大学, 医学医療系, 教授 (90241827)
ISHII Tetsuro 筑波大学, 医学医療系, 教授 (20111370)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 酸化ストレス / 紫外線 / 炎症 |
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| Research Abstract |
The Keap1-Nrf2 system has been identified as an important for preventing cells from oxidative stress damage. In this study, we analyzed peroxiredoxin I(PrxI) which expression is regulated by Keap1-Nrf2 system. We used UVA irradiation as skin wound model, that causes cell apoptosis and inflammation. As a result, the cells derived from PrxI-knockout mice were significantly susceptible to UVA irradiation. It is revealed that PrxI is crucial factor to protect skin from oxidative stress, apoptosis and excess inflammatory response.
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Research Products
(18 results)
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[Presentation] 乳房全摘後の皮弁選択-広背筋皮弁と腹部皮弁2013
Author(s)
関堂 充, 足立 孝二, 佐々木 薫, 阿部 加代子, 坂東 裕子, 田中 優子, 井口 研子, 池田 達彦, 原 尚人, 佐々木 正浩
Organizer
第1回日本乳房オンコプラスティックサージャリー学会総会
Place of Presentation
福岡
Year and Date
2013-09-20
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[Presentation] 手指3度熱傷4例の検討2012
Author(s)
佐々木 薫, 渋谷 陽一郎, 富樫 真二, 足立 孝二, 関堂 充, 久保 諭, 東隆一, 清澤 智晴
Organizer
第55回日本形成外科学会総会・学術集会
Place of Presentation
東京
Year and Date
2012-04-11
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[Presentation] Hausdorff 距離を用いた唇裂手術後の鼻孔形態に関する新しい評価方法2011
Author(s)
輕部 令, 柳川 徹, 富樫 真二, 足立孝二, 大和地 正信, 篠塚 啓二, 石橋直美, 後藤 麻希子, 佐々木 裕芳, 山縣 憲司, 鬼澤 浩司郎, 武川 寛樹
Organizer
第56回日本口腔外科学会総会・学術集会
Place of Presentation
大阪
Year and Date
2011-10-21
