Development of functional artificial dermis and application to intractable skin disease

2015 Fiscal Year Final Research Report

• Project/Area Number: 23390409
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Plastic surgery
• Research Institution: Kyoto University
• Principal Investigator: Kawai Katsuya 京都大学, 医学(系)研究科(研究院), 准教授 (90273458)
• Co-Investigator(Kenkyū-buntansha): SUZUKI SHIGEHIKO 京都大学, 医学研究科, 教授 (30187728) ; MORIMOTO NAOKI 関西医科大学, 医学部, 講師 (40378641)
• Project Period (FY): 2011-04-01 – 2016-03-31
• Keywords: 人工真皮 / 細胞増殖因子 / 難治性皮膚疾患

Outline of Final Research Achievements

Artificial dermis is an artificial material to play the dermis layer of the skin by transplantation on the full-thickness skin defect. However, the wound healing is prolonged in the intractable ulcer. Therefore we have developed a functional artificial dermis, which can be sustained release of cell growth factor (Collagen/Gelatin sponge: CGS).
We examined the effect of wound healing with dual sustained release of basic fibroblast growth factor (bFGF) and hepatocyte growth factor (HGF) bounded electrostatically to the CGS.
By the combination of bFGF and HGF with CGS, granulation tissue formation and epithelialization accelerated , further angiogenic effect has been observeed .

Free Research Field

形成外科