Cell therapy for acute lung injury: possibility of lung derived mesenchymal stem cells

2014 Fiscal Year Final Research Report

• Project/Area Number: 23390411
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: UCHIDA Tokujiro 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (40262183)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 間葉系幹細胞 / 急性肺傷害 / ARDS / 細胞治療

Outline of Final Research Achievements

We recently established a cell culture prepared from lung tissue, which is resistant to trypsin treatment for 16 h. This cell maintained positivity for CD29 and CD 90, and osteogenesis could be induced by osteogenesis inducing media. Also, it abundantly expressed keratinocyte growth factor and released paracrine factors which induced surfactant protein expression in alveolar epithelial cells when it was co-cultured with alveolar epitheilal cells. We demonstrated therapeutic potential of this cell for the mouse lipopolysaccharide induced lung injury model, but further study is needed to establish efficacy of this cell as a clinical therapy option to ARDS.

Free Research Field

麻酔蘇生学