Establishment of a new strategy for the treatment of spinal cord injury: Intrathecal administration of incubated autologous bone marrow stromal cells.

2013 Fiscal Year Final Research Report

• Project/Area Number: 23390414
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Kansai Medical University
• Principal Investigator: NAKATANI Toshio 関西医科大学, 医学部, 教授 (70188978)
• Co-Investigator(Renkei-kenkyūsha): SUZUKI Yoshihisa 田附興風会, 第6研究部, 研究主幹 (30243025) ; IDE Chizuka 藍野大学, 保健医療学部, 教授 (70010080) ; FUKUSHIMA Masanori 先端医療振興財団, 臨床研究情報センター, センター長 (80107820) ; IWASE Masaaki 関西医科大学, 医学部, 准教授 (30247902) ; SAITO Fukuki 関西医科大学, 医学部, 講師 (01046227)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Keywords: 脊髄損傷 / 脊髄再生 / 骨髄単核球 / 髄液内投与 / 骨髄間質細胞 / 四肢麻痺 / 対麻痺 / 運動スコア

Research Abstract

To determine whether intrathecal administration of autologous bone marrow cells is safe and feasible for treatment of subacute spinal injury, five patients with tetraplegia due to cervical spinal injury and 5 with paraplegia due to thoracic spinal injury were included. About 1 million mononuclear cells were obtained from their own iliac bone, and administered immediately into cerebrospinal fluid by lumbar puncture. The patients were closely observed for 6 months. No adverse responses were observed. In a few patients treated earlier, definite motor and sensory recovery was remarkable, but limited in patients treated later. Spinal injury treatment with administration of bone marrow cells into cerebrospinal fluid is safe and feasible underwent in the early subacute phase.

Research Products

• [Journal Article] Bone marrowderived mononuclear cell transplantation in spinal cord injury patients by lumbar puncture (2014)
  • Author(s): Yoshihisa Suzuki, Namiko Ishikawa, Kaoru Omae, Tatsuya Hirai, Katsunori Ohnishi, Norihiko Nakano, Hidetaka Nishida, Toshio Nakatani, Masanori Fukushima, Chizuka Ide
  • Journal Title: Restorative Neurology and Neuroscience Volume: (in press)
  • Peer Reviewed
• [Journal Article] Effects of Bone Marrow Stromal Cell Transplantation through CSF on the Subacute and Chronic Spinal Cord Injury in Rats (2013)
  • Author(s): Norihiko Nakano, Yoshiyasu Nakai, Tae-Beom Seo, Tamami Homma, Yoshihiro Yamada, Masayoshi Ohta, Yoshihisa Suzuki, Toshio Nakatani, Masanori Fukushima, Miki Hayashibe, Chizuka Ide
  • Journal Title: PLOS one Volume: 8巻 Pages: e73494
  • DOI: 10.1371/journal.pone.0073494
  • Peer Reviewed
• [Journal Article] Administration of cultured autologous bone marrow stromal cells into cerebrospinal fluid in spinal injury patients : A pilot study (2012)
  • Author(s): Fukuki Saito, Toshio Nakatani, Masaaki Iwase, Yuji Maeda, Yoshinori Murao, Yoshimasa Suzuki, Masanori Fukushima, Chizuka Ide
  • Journal Title: Restorative Neurology and Neuroscience Volume: 30巻 Pages: 127-136
  • DOI: 10.3233/RNN-2011-0629
  • Peer Reviewed
• [Journal Article] 骨髄間質細胞 (2011)
  • Author(s): 中谷壽男
  • Journal Title: Bone Joint Nerve Volume: 1巻 Pages: 577-582
• [Journal Article] 骨髄間質細胞の髄液内投与 (2011)
  • Author(s): 中谷壽男, 岩瀬正顕, 齊藤福樹, 前田裕仁, 鈴木義久, 福島雅典, 井出千束
  • Journal Title: 整形外科 Volume: 62巻 Pages: 755-760
• [Presentation] Clinical trials for spinal injury treatmment with autologous bone marrow cells administration into cerebrospnal fluid (2013)
  • Author(s): Toshio Nakatani, Yoshimasa Suzuki, Fukuki Saito, Masaaki Iwase, Yuji Maeda, Masanobu Tsuda, Yasuyuki Kuwagata, Masanori Fukushima, Chizuka Ide
  • Organizer: 7th Asian Conference on Emergency Medicine (ACEM2013)
  • Place of Presentation: Tokyo International Forum, Tokyo
  • Year and Date: 2013-10-25
• [Presentation] 脊髄損傷に対する新しい治療法--骨髄由来単核球を用いて-- (2013)
  • Author(s): 齊藤福樹, 津田雅庸, 中谷壽男, 鍬方安行, 岩瀬正顕, 鈴木義久, 井出千束, 福島雅典
  • Organizer: 第28回日本救命医療学会
  • Place of Presentation: 久留米大学筑水会館, 久留米
  • Year and Date: 2013-09-21
• [Presentation] Intrathecal administration of bone marrow mononuclear cells for the treatment of spinal injury ; a clinical trial (2013)
  • Author(s): Toshio Nakatani, Fukuki Saito, Yoshimasa Suzuki, Masanori Fukushima, Chizuka Ide
  • Organizer: International Surgical Week 2013
  • Place of Presentation: Helsinki (Finland)
  • Year and Date: 2013-08-25
• [Presentation] 当院における脊髄損傷に対する再生医療への取り組み (2012)
  • Author(s): 齊藤福樹, 岩瀬正顕, 中谷壽男, 津田雅庸, 前田裕仁, 宮崎秀行, 北元 健, 金沢武哲, 鈴木義久, 井出千束, 福島雅典
  • Organizer: 第40回日本救急医学会総会
  • Place of Presentation: 京都・国立京都国際会館
  • Year and Date: 2012-11-15
• [Presentation] 頸髄外傷の現状と問題点 (2012)
  • Author(s): 岩瀬正顕, 中谷壽男, 淺井昭雄
  • Organizer: 第26回日本外傷学会
  • Place of Presentation: 京都・国立京都国際会館
  • Year and Date: 2012-11-15
• [Presentation] 頸髄外傷の現状と問題点 (2012)
  • Author(s): 岩瀬正顕, 中谷壽男, 淺井昭雄
  • Organizer: 第26回日本外傷学会
  • Place of Presentation: リーガロイヤルホテル東京, 東京
  • Year and Date: 2012-05-25
• [Presentation] ヒト急性期脊髄損傷に対する自家骨髄間質細胞移植~臨床試験までのみちのり~ (2011)
  • Author(s): 齊藤福樹, 岩瀬正顕, 中谷壽男, 鈴木義久, 井出千束, 福島雅典
  • Organizer: 第39回日本救急医学会
  • Place of Presentation: 京王プラザホテル, 東京
  • Year and Date: 2011-10-19