2013 Fiscal Year Final Research Report
Study on the elucidation and prevention for cardiovascular disorder by HACEK group oral bacteria
| Project/Area Number |
23390428
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Okayama University |
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Principal Investigator |
KOKEGUCHI Susumu 岡山大学, 医歯(薬)学総合研究科, 准教授 (10144776)
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Hiroshi 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (00274001)
MURAKAMI Jun 岡山大学, 大学病院, 助教 (40362983)
KARIYAMA Reiko 岡山大学, 大学院・医歯薬学総合研究科, 助教 (40112148)
YOKOTA Kenji 岡山大学, 大学院・保健学研究科, 准教授 (00243460)
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIMURA Fusanori 広島大学, 医歯薬学総合研究科, 教授 (80208222)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 感染症 / 歯周病細菌 / HACEK群細菌 / 心臓・血管疾患 |
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| Research Abstract |
Several microbiologic and epidemiologic studies have suggested an association between oral bacteria and systemic health such as diabetes, respiratory diseases and cardiovascular diseases. The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) among oral bacteria are noted as the pathogens of infective endocarditis. The aim of this study is to determine the possible pathogenic factors of Aggregatibacter actinomycetemcomitans and oral methanogenic Archaea on infective endocarditis, and to analyze clinical and microbiological characteristics of the patients with infective endocarditis. Cell surface enolase and RNA chaperone protein, Hfq in A. actinomycetemcomitans and group II chaperonin of oral methanogenic Archaea were further characterized. The antimicrobial activity of inhibitor for methionine aminopeptidase and vitamin K analogues were also examined as a candidate of new therapeutic agents.
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[Journal Article] 【Helicobacter pylori 感染と生活習慣病2012】 Helicobacter pylori 感染と動脈硬化( 解説/ 特集)2012
Author(s)
小熊惠二, 横田憲治, 松浦栄次, 申蓮花, Dwi Fatmawat, 西田奈々, 江藤真由美, 草地省蔵, 中村一文, 喜多雅英, 武進
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Journal Title
Helicobacter Research
Volume: 16(1)
Pages: 32-39
URL
Peer Reviewed
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[Presentation] Salivary antioxidant activity, cytokines and periodontitis : The Nagasaki island study2013
Author(s)
Tamaki N, Yoshino F, Fukui M, Hayashida H, Yoshida A, Kitamura M, Kawasaki, Nakazato M, Maeda T, Kokeguchi S, Lee MC, Saito T, Ito H-O
Organizer
2nd IADR-APR (asia pacific region)
Place of Presentation
Bangkok, Thailand
Year and Date
20130821-23
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[Presentation] 口腔癌細胞株に対する5-FU・BCG 生菌併用療法の検討2013
Author(s)
李海, 村上純, 大原直也, 中山真彰 , 苔口進, 玉村亮, 辻極秀次, 長塚仁, 此内浩信, 柳文修, 畝坪輝寿, 久富美紀 , 浅海淳一
Organizer
第22回硬組織再生生物学会学術大会・総会
Place of Presentation
神奈川県横浜市
Year and Date
2013-08-22
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[Presentation] 尿路由来メタロ-β-ラクタマーゼ産生緑膿菌のバイオフィルム形成能および分子疫学的検討2012
Author(s)
佐古真一, 狩山玲子, 山本満寿美, 石井亜矢乃, 和田耕一郎, 上原慎也, 渡辺豊彦, 公文裕巳, 光畑律子, 苔口進
Organizer
第60回日本化学療法学会西日本支部総会, 第55回日本感染症学会中日本地方会学術会議, 第82回日本感染症学会西日本地方会学術集会
Place of Presentation
福岡県福岡市
Year and Date
20121105-07
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[Presentation] 播種性淋菌感染症の1例2012
Author(s)
大西信彦, 江原弘貴, 金森達也, 神崎資子, 筑木隆雄, 花山宜久, 草野展周, 大塚文男, 豊岡伸一, 苔口進
Organizer
第107回日本内科学会中国地方会
Place of Presentation
広島県広島市
Year and Date
2012-11-24
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