2013 Fiscal Year Final Research Report
Development of adhesive resins with the function to promote tissue regeneration by release of FGF-2
| Project/Area Number |
23390434
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
IMAZATO Satoshi 大阪大学, 歯学研究科(研究院), 教授 (80243244)
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| Co-Investigator(Kenkyū-buntansha) |
KIBA Wakako 大阪大学, 歯学研究科, 招聘教員 (10523087)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKANO Takayoshi 大阪大学, 工学研究科, 教授 (30243182)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 歯学 / 修復材料 / レジン / 組織再生 / 接着性 / FGF-2 |
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| Research Abstract |
Aiming at achievement of adhesive resins with the function to promote tissue regeneration, novel hydrogel as a carrier of protein was fabricated by copolymerization of HEMA and a cross-linking monomer. The experimental poly-HEMA-based hydrogel particle was effective for loading and long-term release of proteins. The analysis of release kinetics and in vitro cell culture studies demonstrated that FGF-2-releasing particle was successfully developed by loading FGF-2 to the experimental poly-HEMA-based hydrogel particle. In addition, 4-META/MMA-based adhesive resins were found to be possibly combined with theFGF-2-releasing hydrogel particle, and the benefits of combination of these two components were suggested.
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