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2013 Fiscal Year Final Research Report

The basic study of new endodontic therapy induced with cementum

Research Project

  • PDF
Project/Area Number 23390437
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionKanagawa Dental College

Principal Investigator

ISHII Nobuyuki  神奈川歯科大学, 歯学研究科(研究院), 教授 (20163610)

Co-Investigator(Kenkyū-buntansha) TAKAGAKI Yuko  神奈川歯科大学, 大学院・歯学研究科(研究院), 教授 (60050689)
WATANABE Kiyoko  神奈川歯科大学, 大学院・歯学研究科(研究院), 講師 (70148021)
MUTOH Noriko  神奈川歯科大学, 大学院・歯学研究科(研究院), 講師 (40510433)
Project Period (FY) 2011-04-01 – 2014-03-31
Keywords歯学 / 再生医学
Research Abstract

The ideal healing of an endodontic treatment is a mineralized tissue formation on apical foramen. This study aimed at developing the new endodontic treatment which can heal by using Mineral Trioxide Aggregate(MTA) and S-PRG filler by controlling hard tissue formation of the cell which present in the periapical tissue. We used the cells that a human cementblast (HCEM), a human pulp chamber cell (HPulp) and a human periodontal ligament cell (HPLC). The co-culture with MTA and cement containing S-PRG filler. We investigated the expression of genes involved in mineralized tissue formation (Bone Sialoprotein ; BSP, Osteocalcin ; OCN), and mineralization (Alkaline phosphatase ; ALP).It was shown that BSP, OCN and ALP revelation become the maximum in 24 hours and as for all the cells, the potential of mineralized tissue ( bone or cementum) was observed. MTA and S-PRG filler promoting the differentiation induction of HCEM, HPulp, and HPLC participating in the mineralized tissue formation.

  • Research Products

    (2 results)

All 2014

All Presentation (2 results)

  • [Presentation] セメント質誘導を応用した新規歯内治療の基礎的研究2014

    • Author(s)
      武藤徳子, 石井信之
    • Organizer
      第35回日本歯内療法学会学術大会
    • Place of Presentation
      新潟 朱鷺メッセ
    • Year and Date
      20140712-13
  • [Presentation] Mineral trioxide aggregate の根尖部硬組織誘導過程に及ぼす影響に関する研究2014

    • Author(s)
      武藤徳子, 石井信之
    • Organizer
      日本歯科保存学会2014年度春季学術大会(第140回)
    • Place of Presentation
      滋賀 びわ湖ホール
    • Year and Date
      20140619-20

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Published: 2015-06-25  

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