2013 Fiscal Year Final Research Report
Jaw bone regeneration by bone-related protein immobilization to three-dimensional titanium fiber materials
| Project/Area Number |
23390453
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUKUSHIMA Tadao 福岡歯科大学, 再生医学研究センター, 教授 (80084250)
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| Co-Investigator(Renkei-kenkyūsha) |
HIROTA Makoto 横浜市立大学, 大学院・医学研究科, 准教授 (20347305)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 歯科生体材料学 / 再生医学 / チタン / チタンファイバー / チタンワイヤー / タンパク質固定化 / コラーゲン / フィブロネクチン |
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| Research Abstract |
In the present study, protein adsorption towards titanium was first analyzed by quartz-crystal microbalance method and attachment and proliferation of osteoblast-like cells on fibronectin immobilized titanium was also investigated. Afterwards, collagen or fibronectin was immobilized onto three-dimensional titanium fiber web and titanium wire by using tresyl chloride-activation method, and bone regeneration process towards titanium fiber web or titanium wire was evaluated by animal implantation experiments. As a result, it is suggested that protein immobilized titanium fiber web and titanium wire were useful as regenerative materials for jaw bone.
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