2013 Fiscal Year Final Research Report
Practical applications of saliva test to grasp the condition of HIV-1 infected patients
| Project/Area Number |
23390462
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATO Shingo 慶應義塾大学, 医学部, 講師 (10177446)
TANABE Yoshinari 新潟大学, 医歯学系, 助教 (40444161)
NAGATA Masaki 新潟大学, 医歯学総合病院, 講師 (10242439)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | ＨＩＶ / 唾液 / 薬物濃度測定 |
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| Research Abstract |
The aim of our study is to evaluate the efficacy of a regimen or monitor the compliance of patients treated with antiretroviral therapy. Another aim is to develop a method for determination of HIV-1 infection period of novel patients.
First, we established a method to measure drug concentrations in plasma and saliva. Then, we measured drug concentrations in plasma and saliva and found significant correlations were evident between drug concentrations in saliva and those in plasma, so the possibility of using saliva was suggested. Second, we generated a hypothesis that HIV-1 infected patient's saliva have no infectivity because HIV-1 RNA in saliva were damaged. Then, we established a method for validate this hypothesis.
These studies are valuable for HIV-1 infected patients with more convenient clinical examination or determination for the period of HIV-1 infection.
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[Presentation] 抗HIV 薬の唾液中薬剤濃度の検討2014
Author(s)
山田瑛子, 高木律男, 田邊嘉也, 永井孝宏, 村山正晃, 池野 良, 児玉泰光, 親泊あいみ, 須藤弘二, 戸蒔祐子, 藤原 宏, 長谷川直樹, 岩田 敏, 加藤真吾
Organizer
第14回日本HIV歯科医療研究会
Place of Presentation
東京都千代田区
Year and Date
20140111-12
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[Presentation] 抗HIV薬の唾液中薬剤濃度の検討2013
Author(s)
山田瑛子, 高木律男, 田邊嘉也, 永井孝宏, 村山正晃, 池野 良, 児玉泰光, 親泊あいみ, 須藤弘二, 戸蒔祐子, 藤原 宏, 長谷川直樹, 岩田 敏, 加藤真吾
Organizer
第27回日本エイズ学会学術集会・総会
Place of Presentation
熊本市
Year and Date
20131120-22
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