• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2013 Fiscal Year Final Research Report

Molecular analysis of inflammasome in periodontal tissue destruction and regeneration.

Research Project

  • PDF
Project/Area Number 23390478
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionOsaka University

Principal Investigator

YAMADA SATORU  大阪大学, 歯学部附属病院, 講師 (40359849)

Co-Investigator(Kenkyū-buntansha) MURAKAMI Shinya  大阪大学, 大学院・歯学研究科, 教授 (70239490)
KITAMURA Masahiro  大阪大学, 大学院・歯学研究科, 准教授 (10243247)
YANAGITA Manabu  大阪大学, 大学院・歯学研究科, 助教 (80379081)
SAITO Masahiro  東北大学, 大学院・歯学研究科, 教授 (40215562)
Co-Investigator(Renkei-kenkyūsha) YAMAMOTO Teruko  東北大学, 大学院・歯学研究科, 教授 (00127250)
MORISAKI Takayuki  国立循環器病研究センター, 分子生物学部, 部長 (30174410)
Project Period (FY) 2011-04-01 – 2014-03-31
Keywords歯周組織 / インフラマソーム / ECM分子
Research Abstract

In this study, we investigated expression pattern of inflammasome in periodontal tissue and cells to assess the involvement of inflammasome in periodontal tissue homeostasis, destruction and regeneration. It was shown that inflammasome-associated molecules are expressed in periodontal tissues and cells in normal conditions and these expressions are up-regulated in inflammatory conditions. Periodontal ligament associated extracellular matrix (PDL-ECM) proteins show the interaction with inflammasome, suggesting the regulation of tissue-homeostasis and inflammatory responses by PDL-ECM-inflammasome pathway.

  • Research Products

    (7 results)

All 2014 2013 2012 2011

All Journal Article (4 results) Presentation (3 results) (of which Invited: 2 results)

  • [Journal Article] Characterization of a novel periodontal ligament specific periostin isoform2014

    • Author(s)
      S. Yamada, T. Tauchi, T. Awata, K. Maeda, T. Kajikawa, M. Yanagita, S. Murakami
    • Journal Title

      Journal of Dental Research

      Volume: (in press)

  • [Journal Article] Inhibitory effects of PLAP-1/asporin on periodontal ligament cells2014

    • Author(s)
      T. Kajikawa, S. Yamada, T. Tauchi, T. Awata, S. Yamaba, C. Fujihara, S. Murakami
    • Journal Title

      Journal of Dental Research

      Volume: 93(4) Pages: 400-405

    • DOI

      10.1177/0022034513520549

  • [Journal Article] Iron plays a key role in the cytodifferentiation of human periodontal ligament cells2013

    • Author(s)
      J. Hou, S. Yamada, T. Kajikawa, N. Ozaki, T. Awata, C. Fujihara, S. Murakami
    • Journal Title

      Journal of Periodontal Research

      Volume: (in press)

    • DOI

      10.1111/jre.12103

  • [Journal Article] Role of ferritin in the cytodifferentiation of periodontal ligament cells2012

    • Author(s)
      J. Hou, S. Yamada, T. Kajikawa, N. Ozaki, T. Awata, S. Yamaba, S. Murakami
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 5; 426(4) Pages: 643-648

    • DOI

      10.1016/j.bbrc.2012.09.008

  • [Presentation] Molecular basis of periodontal ligament : Identification and characterization of periodontal ligament specific molecule, PLAP-12014

    • Author(s)
      S. Yamada
    • Organizer
      International scientific meeting at University Gadjah Mada
    • Place of Presentation
      ジョグジャカルタ, インドネシア
    • Year and Date
      2014-02-28
  • [Presentation] 歯周組織の恒常性維持と破綻の分子メカニズム2013

    • Author(s)
      山田 聡
    • Organizer
      第67回日本口腔科学会
    • Place of Presentation
      宇都宮市
    • Year and Date
      2013-05-23
    • Invited
  • [Presentation] 網羅的遺伝子解析が担う歯周病研究の未来2011

    • Author(s)
      山田 聡
    • Organizer
      第135回日本歯科保存学会
    • Place of Presentation
      大阪市
    • Year and Date
      2011-10-21
    • Invited

URL: 

Published: 2015-06-25  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi