2013 Fiscal Year Final Research Report
Effect of senescent adipose tissue on periodontal disease states
| Project/Area Number |
23390482
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Social dentistry
|
|---|
| Research Institution | Kyushu Dental College |
|---|
Principal Investigator |
AKIFUSA Sumio 九州歯科大学, 歯学部, 教授 (40295861)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKATA Yutaka 九州歯科大学, 歯学部, 教授 (40163208)
NISHIHARA Tatsuji 九州歯科大学, 歯学部, 教授 (80192251)
|
|---|
| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Keywords | アディポカイン / apelin / 歯周疾患 |
|---|
| Research Abstract |
we investigated whether newly identified adipokine apelin had an inhibitory effect on inflammatory response in lipopolysaccharide (LPS) -treated macrophage. Pretreatment with apelin significantly reduced the production of proinflammatory cytokines in LPS-treated macrophage-like cell line, J774.1 cell. In addition, apelin pretreatment significantly reduced the LPS-induced phosphorylation of p38 MAPK and JNK, but not ERK. To the best of our knowledge, this is the first report that the apelin peptide family has anti-inflammatory effects against bacterial LPS stimulation in macrophages.
|
-
[Journal Article] Gender differences in the association between metabolic syndrome and periodontal disease : the Hisayama Study2013
Author(s)
Furuta M, Shimazaki Y, Takeshita T, Shibata Y, Akifusa S, Eshima N, Kiyohara Y, Ninomiya T, Hirakawa Y, Mukai N, Nagata M, Yamashita Y
-
Journal Title
J Clin Periodontol
Volume: 40(8)
Pages: 743-752
DOI
Peer Reviewed
-
[Journal Article] High-level activities of daily living and disease-specific mortality during a 12-year follow-up of an octogenarian population2013
Author(s)
Takata Y, Ansai T, Soh I, Awano S, Nakamichi I, Akifusa S, Goto K, Yoshida A, Fujii H, Fujisawa R, Sonoki K
-
Journal Title
Clin Interv Aging
Volume: 8
Pages: 721-728
DOI
Peer Reviewed
-
-
[Journal Article] Body mass index and disease-specific mortality in an 80-year-old population at the 12-year follow-up2013
Author(s)
Takata Y, Ansai T, Soh I, Awano S, Nakamichi I, Akifusa S, Goto K, Yoshida A, Fujii H, Fujisawa R, Sonoki K
-
Journal Title
Arch Gerontol Geriatr
Volume: 57(1)
Pages: 46-53
DOI
Peer Reviewed
-
-
-
[Journal Article] Interrelationship of oral health status, swallowing function, nutritional status, and cognitive ability with activities of daily living in Japanese elderly people receiving home care services due to physical disabilities2013
Author(s)
Furuta M, Komiya-Nonaka M, Akifusa S, Shimazaki Y, Adachi M, Kinoshita T, Kikutani T, Yamashita Y
-
Journal Title
Community Dent Oral Epidemiol
Volume: 41(2)
Pages: 173-181
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
[Book] Association of disease-specific mortality with fitness measurements and nonparticipation in an 80-year-old population. In : Geriatrics2012
Author(s)
Takata, Y., Ansai, T., Soh, I., Awano, S., Yoshitake, Y., Kimura, Y., Nakamichi, I., Akifusa, S., Goto, K., Yoshida, A., Fujisawa, R., Sonoki, K, Nishihara, T
Total Pages
59-82
Publisher
InTech
-
