Research on the anticancer effects and multidrug-resistance modulating effects of Thai plants

2014 Fiscal Year Final Research Report

• Project/Area Number: 23406005
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Medical pharmacy
• Research Institution: Hiroshima University
• Principal Investigator: TAKANO Mikihisa 広島大学, 医歯薬保健学研究院(薬), 教授 (20211336)
• Co-Investigator(Renkei-kenkyūsha): YUMOTO Ryoko 広島大学, 大学院医歯薬保健学研究院, 講師 (70379915)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 薬学 / タイ植物 / がん治療 / 抗がん作用 / 耐性克服作用

Outline of Final Research Achievements

Ten extracts from Thai plants belonging to the families of Annonaceae, Rutaceae, and Zingiberaceae were obtained, in order to test anticancer effects and multidrug-resistance modulating (P-glycoprotein inhibiting) effects. The extract from Ellipeiopsis cherrevensis showed potent anticancer effects under in vitro as well as in vivo conditions, and the extract was found to induce necrosis in cancer cells. The extracts from Curcuma comosa and Kaempferia marginata showed potent P-glycoprotein inhibitory effects. These Thai plants would be a useful source to search for new anticancer drugs and multidrug-resistance modulators.

Free Research Field

薬学