2013 Fiscal Year Final Research Report
The genomic epidemiology and immunological cohort study on amoebiasis in South Asia
| Project/Area Number |
23406009
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KATO Kentaro 長崎大学, 熱帯医学研究所, 助教 (50508885)
MIICHI Fumika 佐賀大学, 医学部, 助教 (70576818)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 赤痢アメーバ / 新生児 / 乳児 / コホート研究 / Entamoeba histolytica / Entamoeba moshkovskii / 南アジア / バングラディシュ |
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| Research Abstract |
In Mirpur, Dhaka, Bangladesh, natural exposure to Entamoeba spp. in infancy was prospectively observed. Approxymately, 80% of children had been infected with Entamoeba histolytica by age two years, with around 20% having suffered from E. histolytica. Furthermore, newly acquired E. moshkovskii infection was associated with diarrhea. Genetic analysis revealed that E. moshkovskii isolates infecting children were genetically heterogeneous, as evidenced by PCR typing of tRNA locus R-R. It will be important in future studies of the potential pathogenicity of E. moshkovskii to take into account this heterogeneity, as for the case of E. histolytica, not every genotype is equally capable of causing disease.
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[Journal Article] Species-specific immunity induced by infection with Entamoeba histolytica and Entamoeba moshkovskii in mice2013
Author(s)
Shimokawa, C., Culleton, R., Imai, T., Suzue, K., Hirai, M., Taniguchi, T., Kobayashi, S., Hisaeda, H., Hamano, S
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Journal Title
PLoS One
Volume: 8(11)
Pages: e82025
DOI
Peer Reviewed
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[Journal Article] Entamoeba moshkovskii is associated with diarrhea in infants and causes diarrhea and colitis in mice2012
Author(s)
Shimokawa, C., Kabir, M., Taniuchi, M., Mondal, D., Kobayashi, S., Ali, I.K., Sobuz, S., Senba, M., Houpt, E., Haque, R., Petri, W.A., Hamano, S
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Journal Title
J. Infect. Dis
Volume: 206(5)
Pages: 744-751
Peer Reviewed
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[Presentation] Entamoeba moshkovskii is associated with diarrhea in infants and causes diarrhea and colitis in mice2013
Author(s)
Shimokawa C, Kabir M, Taniuchi M, Mondal D, Kobayashi S, Ali IK, Sobuz SU, Senba M, Houpt E, Haque R, Petri WA Jr, Hamano S
Organizer
The XVII Amibiasis Meeting
Place of Presentation
Merida, Mexico
Year and Date
20130201-05
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[Presentation] Entamoeba moshkovskii is associated with diarrhea in infants and causes diarrhea and colitis in mice2012
Author(s)
Chikako Shimokawa, Mamum Kabir, Mami Taniuchi, Dinesh Mondal, Seiki Kobayashi, Ibne Karim M. Ali, Masachika Senba, Eric Hoput, Haque Rashidul, William A. Petri Jr., Shinjiro Hamano
Organizer
第81回日本寄生虫学会総会
Place of Presentation
神戸
Year and Date
2012-03-23
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[Presentation] Entamoeba moshkovskii is pathogenic and causes intestinal symptoms2011
Author(s)
Chikako Shimokawa, Mamum Kabir, Mami Taniuchi, Dinesh Mondal, Seiki Kobayashi, Ibne Karim M. Ali, Masachika Senba, Eric Hoput, Haque Rashidul, William A. Petri Jr., Shinjiro Hamano
Organizer
The 60th annual meeting of American society of tropical medicine and hygiene
Place of Presentation
Philadelphia
Year and Date
20111204-08
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