2013 Fiscal Year Final Research Report
Molecular epidemiology of tick borne-emerging infectious disease, Anaplasmosis, Spotted fever, and Lyme borreliosis in East Asian countries.
| Project/Area Number |
23406012
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Chiba Institute of Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKADA Nobuhiro 福井大学, 医学部, シニアフェロー (90003409)
OHASHI Norio 静岡県立大学, 食品栄養学部, 教授 (10169039)
KADOSAKA Teruki 愛知医科大学, 医学部, 講師 (90109760)
OIKAWA Yosaburo 金沢医科大学, 医学部, 医学部 (10139785)
NATSUAKI Masaru 兵庫医科大学, 医学部, 准教授 (60208072)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | アナプラズマ / ヒト顆粒球アナプラズマ症 / ボレリア / ライム病 / ダニ媒介性感染症 / シュルツェマダニ / 紅斑熱 |
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| Research Abstract |
The prevalence of human granulocytic anaplasmosis (HGA) agent, Anaplasma phagocytophilum and relapsing fever agent, Borrelia miyamotoi, in reservoir animals and vector ticks in East Asia, including Japan, were examined. Anaplasma was detected from Ixodes persulcatus ticks collected in Irkutsk, Khabarovsk, and Selenge in Mongolia. In Kochi Prefecture, Japan, two patients were confirmed retrospectively to be infected with Anaplasma and the agent detected was similar to those from ticks collected in far-east Russia. Relapsing fever-causing Borrelia was detected in ticks collected in Irkutsk and Khabarovsk, indicating that relapsing fever should be involved in the diagnosis of tick bite patients. Variant Anaplasma was detected in wild rodents captured in Taiwan. This agent has not been found in ticks collected in Taiwan and also China.
Polysaccharide antigen extracted from spotted fever Rickettsia under alkaline condition could be used as antigen for Dot-ELISA-based serodiagnosis.
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Research Products
(36 results)
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[Journal Article] Construction of a DNA database for ticks collected in Japan : application of molecular identification based on the mitochondrial 16SrDNA gene2014
Author(s)
Takano I, Fujita H, Kadosaka T, Takahashi M, Yamauchi T, Ishiguro F, Takada N, Yano Y, Oikawa Y, Honda T, Gokuden M, Tsunoda T, Tsurumi M, Ando S, Andoh M, Sato K, Kawabata, H
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Journal Title
Med. Entomol. Zool
Volume: 65
Pages: 13-21
Peer Reviewed
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[Journal Article] Construction of a DNA database for ticks collected in Japan : application of molecular identification based on the mitochondrial 16S rDNA gene2014
Author(s)
Takano A, Fujita H, Kadosaka T, Takahashi M, Yamauchi T, Ishiguro F, Takada N, Yano Y, Oikawa Y, Honda T, Gokuden M, Tsunoda T, Turumi M, Ando S, Andoh M, Sato K, Kawabata H
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Journal Title
Med. Entomol. Zool
Volume: 65(1)
Pages: 13-21
Peer Reviewed
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[Journal Article] Human granulocytic Anaplasmosis2013
Author(s)
Ohashi, N., Gaowa, Wuritu, Kawamori, F., Wu, D., Yoshikawa, Y., Chiya, S., Fukunaga, K., Funato, T., Shiojiri, M., Nakajima, H., Hamauzu, Y., Takano, A., Kawabata, H., Ando, S., Kishimoto, T
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Journal Title
Japan. Emerg Infect Dis
Volume: 19
Pages: 289-292
Peer Reviewed
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[Journal Article] Rickettsiae in ticks2013
Author(s)
Gaowa, Ohashi, N., Aochi, M., Wuritu, Wu, D., Yoshikawa, Y., Kawamori, F., Honda, T., Fujita, H., Takada, N., Oikawa, Y., Kawabata, H., Ando, S., and Kishimoto, T
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Journal Title
Japan. Emerg. Infect. Dis
Volume: 19
Pages: 338-340
Peer Reviewed
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[Journal Article] Multilocus sequence typing and DNA similarity analysis implicate Borrelia valaisiana-related sp. isolated in Japan is distinguishable from European B. valaisiana2013
Author(s)
Kawabata H, Takano A, Kadosaka T, Fujita H, Nitta Y, Gokuden M, Honda T, Tomida J, Kawamura Y, Masuzawa T, Ishiguro F, Takada N, Yano Y, Andoh M, Ando S, Sato K, Takahashi H, Ohnishi M
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Journal Title
J. Vet. Med. Sci.
Volume: 75
Pages: 1201-1207
Peer Reviewed
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[Journal Article] Detection and characterization of p44/msp2 transcript variants of Anaplasma phagocytophilum from naturally infected ticks and wild deer in Japan2012
Author(s)
Gaowa, Wuritu, Wu D, Yoshikawa Y, Ohashi N, Kawamori1 F, Sugiyama K, Ohtake M, Ohashi M, Yamamoto S, Kitano T, Takada N, and Kawabata H
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Journal Title
Jpn. J. Infect. Dis
Volume: 65
Pages: 79-83
Peer Reviewed
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[Presentation] 極東ロシアとモンゴル由来シュルツェマダニの回帰熱ボレリアの保有状況2014
Author(s)
増澤俊幸, 宮井莉奈, 益田翔, 川端寛樹, 高野愛, Maxim Khasnatinov, 大橋典男, 高田伸弘, Jantsandoo Bataa, 岡本能弘, 福井貴史
Organizer
第51回レプトスピラシンポジウム
Place of Presentation
東京
Year and Date
2014-03-29
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[Presentation] 並びにモンゴル由来マダニのヒト顆粒アナプラズマとライム病ボレリアの共感染2013
Author(s)
増澤俊幸, 益田翔, 宮井莉奈, 福井貴史, 岡本能弘, 大橋典男, Wuritu , 高田伸弘, Khasnatinov, M. A., Danchinova G. A., Ivanov, L. I., Bataa, J:極東ロシア
Organizer
第13回人と動物の共通感染症研究会
Place of Presentation
東京
Year and Date
2013-11-02
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[Presentation] 極東ロシア, モンゴルにおけるヒト顆粒球アナプラズマの検出2013
Author(s)
益田翔, 増澤俊幸, 岡本能弘, 福井貴史, 大橋典男, Khasnatinov, M. A., Danchinova G. A., Ivanov, L. I., Jantsandoo Bataa, 及川陽三郎, 石畝史, 高田伸弘
Organizer
第21回SDAI
Place of Presentation
稚内
Year and Date
2013-06-22
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[Presentation] Comparative research of Anaplasma in Japan and other countries. Russian Scientific conference with international participation "BASIC AND APPLIED ASPECTS OF INFECTIOUS PATHOLOGY", devoted to 100-year anniversary of the Institute of epidemiology and microbiology2012
Author(s)
Masuzawa T, Ohashi N, Khasnatinov M, Danchinova D, Ivanov L, Fukui T, Okamoto Y, Pan M, Koizumi NComparative research of Anaplasma in Japan and other countries. Russian Scientific conference with international participation "BASIC AND APPLIED ASPECTS OF INFECTIOUS PATHOLOGY", devoted to 100-year anniversary of the Institute of epidemiology and microbiology
Organizer
SC FHHRP SB RAMS
Place of Presentation
Irkutsk, Russia
Year and Date
20120927-28
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[Presentation] Molecular epidemiological study of Rickettsiales bacteria in wild deer and mice in Shizuoka prefecture, Japan2011
Author(s)
Wuritu, Wu D., Yoshikawa Y., Furukawa E., Murakami T., Minato C., Kawamori F., Ohtake M., Ohashi M. and Ohashi N
Organizer
International Union of Microbiological Societies 2011 Congress
Place of Presentation
Sapporo, Japan
Year and Date
2011-09-09
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[Presentation] Molecular detection of tick-borne pathogens, Anaplasma phagocytophilum and Borrelia burgdorferi, from vector tick, Ixodes ricinus, collected in the Istanbul metropolitan area and rural Trakya (Thrace) region of Turkey2011
Author(s)
Masuzawa T, Sen E, Uchishima Y, Okamoto Y, Fukui T, Kadosaka T, and Ohashi N
Organizer
International Union of Microbiological Societies 2011 Congress
Place of Presentation
Sapporo
Year and Date
2011-09-07
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