2014 Fiscal Year Final Research Report
Survey of viral neutralizing antibody against rabies for the elimination of rabies from southeastern endemic countries
| Project/Area Number |
23406014
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Virology
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
AHMED Kamruddin 大分大学, 全学研究推進機構, 准教授 (00398140)
YAMADA Kentaro 大分大学, 全学研究推進機構, 助教 (70458280)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Keywords | 狂犬病 / 中和抗体 / ワクチン / アジア |
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| Outline of Final Research Achievements |
countries. Post-exposure vaccination in human and mass vaccination of dogs is the most rational strategy for reducing rabies victims or interrupting the natural transmission cycle of rabies. To know viral neutralizing antibody (VNA) level against rabies virus rapidly and easily is essential not only for evaluating protective immunity of humans and dogs but also for strategy for eradication program. Our newly developed RAPINA is a method which can determine the VNA easily, rapidly, and low-cost.We reported the performance of the RAPINA for evaluating vaccination status of the humans and dogs by multicenter comparison in Asia. Compared to the VNA level determined by standard neutralizing test, positive and negative predicted values and concordance ratio of RAPINA were highly homologous and reproducible among different laboratories. We concluded that the RAPINA will be effective tool for monitoring vaccination coverage in resource-limited countries.
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| Free Research Field |
ウイルス学
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