2014 Fiscal Year Final Research Report

Reproductive and developmental effects of lead and other trace metals:international collaboration studies between Japan, China, Indonesia, and Iran

Research Project

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Project/Area Number	23406024
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	海外学術
Research Field	Hygiene and public health
Research Institution	Juntendo University
Principal Investigator	YOKOYAMA Kazuhito 順天堂大学, 医学部, 教授 (00158370)
Co-Investigator(Kenkyū-buntansha)	TAKEDA Satoru 順天堂大学, 医学部, 教授 (20143456) SHIMIZU Toshiaki 順天堂大学, 医学部, 教授 (30260889) CHIBA Momoko 順天堂大学, 医学部, 客員教授 (80095819) SHINOHARA Atsuko 清泉女子大学, 人文科学研究所, 教授 (90157850) VIEGH Mohsen 労働安全衛生総合研究所, 研究員 (80455485)
Co-Investigator(Renkei-kenkyūsha)	NISHIOKA Emiko 防衛医科大学, 看護学部, 教授 (70550797) KITAMURA Fumihiko 順天堂大学, 医学部, 准教授 (20301145) HOSOKAWA Mayuko 順天堂大学, 医学部, 助教 (70582013) MATSUKAWA Takehisa 順天堂大学, 医学部, 助教 (60453586)
Project Period (FY)	2011-04-01 – 2015-03-31
Keywords	小児 / 微量元素 / 環境 / 健康影響
Outline of Final Research Achievements	We have conducted epidemiological surveys on the reproductive and developmental effects of lead and other trace metals in Tehran, Dalian, Serpong and Tokyo. The survey in Tehran, we revealed that a relatively low level of prenatal lead exposure (mean < 6.5 micro-g/dL) associated with lower developmental scores in early childhood. The survey in Dalian revealed that newborn birth weight were affected by manganese concentration in mother whole blood and/or umbilical cord blood. The survey in Serpong revealed that lower socioeconomic status were associated with increased blood lead concentrations, especially in female children. The survey in Tokyo suggested that very low-level exposure to lead ( < 5.0 micro-g/dL) in early gestation could be a risk factor for reduced birth weight in male offspring. Lead, manganese and other metals may cause adverse reproductive and developmental effects at levels believed to be safe.
Free Research Field	衛生学、環境医学