Interaction between local and global coding in learning and memory

2014 Fiscal Year Final Research Report

• Project/Area Number: 23500186
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Intelligent informatics
• Research Institution: Kawasaki University of Medical Welfare
• Principal Investigator: FUKUSHIMA Yasuhiro 川崎医療福祉大学, 医療福祉学部, 講師 (00384719)
• Co-Investigator(Kenkyū-buntansha): TSUKADA Minoru 玉川大学, 脳科学研究所, 客員教授 (80074392) ; TSUDA Ichiro 北海道大学, 電子科学研究所, 教授 (10207384) ; YAMAGUTI Yutaka 北海道大学, 電子科学研究所, 助教 (80507236) ; AIHARA Takeshi 玉川大学, 理工学研究科, 教授 (70192838)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 時空間コーディング / 学習と記憶 / 海馬 / 高速アンケージングシステム / 理論と実験の融合

Outline of Final Research Achievements

In our study,　interaction of the spatiotemporal learning rule (non-Hebbian, bottom-up, i.e. "local") and the Hebbian learning (Top-down, i.e. "global") are experimentally and theoretically investigated in hippocampal system. To clarify the detail properties of the information of spatiotemporal sequence affects the postsynaptic membrane potentials of single pyramidal cells in the hippocampus, the stimuli of the spatio-temporal pattern were applied using high-speed uncaging system. Our results show non-linear property of Cantor coding in steady and non-steady states, and discussed in relation to theoretical model for learning and memory.

Free Research Field

神経科学