Establishment and application of a general linear quadratic model that incorporates the time factor

2015 Fiscal Year Final Research Report

• Project/Area Number: 23500369
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Bioinformatics/Life informatics
• Research Institution: Jikei University School of Medicine
• Principal Investigator: Sekine Hiroshi 東京慈恵会医科大学, 医学部, 教授 (40187852)
• Project Period (FY): 2011-04-28 – 2016-03-31
• Keywords: 放射線治療 / 分割照射 / 時間線量分割関係 / LQモデル / GLQモデル / 放射線感受性 / 放射線性紅斑 / 放射線皮膚炎

Outline of Final Research Achievements

Treatment effect of fractionated radiotherapy is defined by fractionated dose, fractionation interval, and the number of fractionation. Although traditional LQ model has variables of fractionated dose and the number of fractionation, it has not variable of fractionated interval. Therefore, this model can’t explain decline of local control after long time treatment split. Then, we developed GLQ model considering fractionated interval. This model explains following situations: It can compare the treatment effect of the various fractionation regimen. It proved that there is a possibility that the non-uniform radiosensitivity of the tumor participates in local recurrence after radiotherapy. It proved to be able to reproduce the radiation dermatitis which changes with time.
http://www.radbiolog.jp

Free Research Field

放射線治療