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2013 Fiscal Year Final Research Report

Development of quantitative evaluation methods for high-resolution Ca2+ imaging data

Research Project

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Project/Area Number 23500375
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Bioinformatics/Life informatics
Research InstitutionTokyo Institute of Technology

Principal Investigator

AONISHI Toru  東京工業大学, 総合理工学研究科(研究院), 准教授 (00333352)

Co-Investigator(Renkei-kenkyūsha) MIYAKAWA Hiroyoshi  東京薬科大学, 生命科学部, 教授 (90166124)
Project Period (FY) 2011 – 2013
Keywordsカルシュムイメージング / 状態空間モデル / ベイズ統計 / 樹状突起 / カルシウムウエーブ / 粒子フィルタ / 非負値行列因子分解
Research Abstract

Recently, Ca2+ imaging techniques, which have progressed rapidly in recent years, enable us to observe the behavior of intracellular Ca2+ under high resolution. We aim to develop analytical methods for high-resolution Ca2+ imaging data. Research project I: We developed a Bayesian statistical method to estimate intracellular Ca2+ concentration from Ca2+ fluorescence intensities. We used state space modeling method to formulate the observation process of Ca2+ fluorescence intensities. Research project II: We proposed a statistical scheme for the quantitative estimate of Ca2+ wave from spatiotemporal Ca2+ imaging data based on a state space modeling of dendritic Ca2+ diffusion process. Research project III: We developed a cell detection algorithm using non-negative matrix factorization on Ca2+ imaging data. We demonstrated that our method could decompose rapid transient components corresponding to somas and dendrites of many neurons.

  • Research Products

    (28 results)

All 2014 2013 2012 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 11 results) Presentation (13 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Detecting cells using non-negative matrix factorization on calcium imaging data2014

    • Author(s)
      Ryuichi Maruyama, Kazuma Maeda, Hajime Moroda, Ichiro Kato, Masashi Inoue, Hiroyoshi Miyakawa and Toru Aonishi
    • Journal Title

      Neural Networks

      Volume: 55C Pages: 11-19

    • DOI

      10.1016/j.neunet.2014.03.007

    • Peer Reviewed
  • [Journal Article] Cooperative integration and representation underlying bilateral network of fly motion-sensitive neurons2013

    • Author(s)
      Yoshinori Suzuki, Takako Morimoto, Hiroyoshi Miyakawa and Toru Aonishi
    • Journal Title

      PLOS ONE

      Volume: 9(1) Pages: e85790

    • DOI

      10.1371/journal.pone.0085790

    • Peer Reviewed
  • [Journal Article] Experience-dependent Plasticity of the Optomotor Response in Drosophila melanogaster2013

    • Author(s)
      Akiko Kikuchi, Shumpei Ohashi, Naoyuki Fuse, Toshiaki Ohta, Marina Suzuki, Yoshinori Suzuki, Tomoyo Fujita, Takuya Miyamoto, Toru Aonishi, Hiroyoshi Miyakawa and Takako Morimoto
    • Journal Title

      Developmental Neuroscience

      Volume: 34(6) Pages: 533-42

    • DOI

      10.1159/000346266

    • Peer Reviewed
  • [Journal Article] Properties of associative memory model with the β-th-order synaptic decay2013

    • Author(s)
      Ryota Miyata, Toru Aonishi , Koji Kurata
    • Journal Title

      IPSJ Transactions on Mathematical Modeling and Its Applications

      Volume: 6 Pages: 134-139

    • DOI

      10.2197/ipsjtrans.7.27

    • Peer Reviewed
  • [Journal Article] Optimal Design for Hetero-Associative Memory : Hippocampal CA1 Phase Response Curve and Spike-Timing-Dependent Plasticity2013

    • Author(s)
      Ryota Miyata, Keisuke Ota and Toru Aonishi
    • Journal Title

      PLOS ONE

      Volume: 8(10) Pages: e77395

    • DOI

      10.1371/journal.pone.0077395

    • Peer Reviewed
  • [Journal Article] Low-frequency dielectric dispersion of brain tissue due to electrically long neurites2012

    • Author(s)
      Hiromu Monai, Masashi Inoue, Hiroyoshi Miyakawa and Toru Aonishi
    • Journal Title

      Physical Review E

      Volume: 86(6) Pages: 061911

    • DOI

      10.1103/PhysRevE.86.061911

    • Peer Reviewed
  • [Journal Article] Higher-order Spike Triggered Analysis of Neural Oscillators2012

    • Author(s)
      Keisuke Ota, Toshiaki Omori, Hiroyoshi Miyakawa, Masato, Okada and Toru Aonishi
    • Journal Title

      PLOS ONE

      Volume: 7(11) Pages: e50232

    • DOI

      10.1371/journal.pone.0050232

    • Peer Reviewed
  • [Journal Article] Estimating Membrane Resistance over Dendrite Using Markov Random Field2012

    • Author(s)
      Jun Kitazono, Toshiaki Omori, Toru Aonishi and Masato Okada
    • Journal Title

      情報処理学会論文誌. 数理モデル化と応用

      Volume: 5(3) Pages: 89-94

    • DOI

      10.2197/ipsjtrans.5.186

    • Peer Reviewed
  • [Journal Article] Sparsely Encoded Hopfield Model with Unit Replacement2012

    • Author(s)
      Ryota MIYATA, Koji KURATA and Toru AONISHI
    • Journal Title

      IEICE TRANSACTIONS on Information and Systems

      Volume: Vol.E95-D, No.8 Pages: 2124-2132

    • DOI

      10.1587/transinf.E95.D.2124

    • Peer Reviewed
  • [Journal Article] Properties of Hopfield model with the zero-order synaptic decay2012

    • Author(s)
      Ryota Miyata, Toru Aonishi, Jun Tsuzurugi and Koji Kurata
    • Journal Title

      ARTIFICIAL LIFE AND ROBOTICS

      Volume: 17(1) Pages: 163-167

    • DOI

      10.1007/s10015-012-0033-5

    • Peer Reviewed
  • [Journal Article] ベイズ推定法による定量的カルシウム動態推定2012

    • Author(s)
      角田敬正, 織田善晃, 大森敏明, 井上雅司, 宮川博義, 岡田真人, 青西 亨
    • Journal Title

      電子情報通信学会技術研究報告

      Volume: NC2011-175 Pages: 317-322

  • [Journal Article] Measurement of infinitesimal phase response curves from noisy real neurons2011

    • Author(s)
      Keisuke Ota, Toshiaki Omori, Shigeo Watanabe, Hiroyoshi Miyakawa, Masato, Okada and Toru Aonishi
    • Journal Title

      Physical Review E

      Volume: 84 Pages: 041902

    • DOI

      10.1103/PhysRevE.84.041902

    • Peer Reviewed
  • [Presentation] Optimal pair of coupling function and STDP window function for auto-associative memory2013

    • Author(s)
      Ryota Miyata, Keita Sato, Toru Aonishi
    • Organizer
      The 20th International Conference on Neural Information Processing (ICONIP 2013)
    • Place of Presentation
      EXCO, Daegu, Korea
    • Year and Date
      2013-11-05
  • [Presentation] Optimal pair of hippocampal CA1 phase response curve and spike-timing-dependent plasticity for hetero-associative memory2013

    • Author(s)
      Ryota Miyata, Keisuke Ota, Toru Aonishi
    • Organizer
      The 22nd Annual Computational Neuroscience Meeting (CNS 2013)
    • Place of Presentation
      The Universite Paris Descartes, Paris, France
    • Year and Date
      2013-07-14
  • [Presentation] Characteristics prediction of STDP in hippocampal CA1 network by mutual information maximization2013

    • Author(s)
      Ryota Miyata, Keisuke Ota and Toru Aonishi
    • Organizer
      Computational and Systems Neuroscience (COSYNE) 2013
    • Place of Presentation
      Salt Lake City(USA)
    • Year and Date
      2013-03-01
  • [Presentation] Model study on recurrent network integrating binocular information in fly visual system2012

    • Author(s)
      Yoshinori Suzuki, Takako Morimoto, Hiroyoshi Miyakawa, Toru Aonishi
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      New Orleans(USA)
    • Year and Date
      2012-10-16
  • [Presentation] Possible contribution of passive membrane properties of dendrites on dielectric properties of neural tissues -An analytic solution of the extended cable equation including the extracellular media-2012

    • Author(s)
      H. Monai, H. Miyakawa, and T. Aonishi
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      New Orleans(USA)
    • Year and Date
      2012-10-16
  • [Presentation] Characteristics prediction of spike-timing-dependent plasticity in hippocampal CA1 network by mutual information maximization2012

    • Author(s)
      Ryota Miyata, Keita Sato, Toru Aonishi
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      New Orleans(USA)
    • Year and Date
      2012-10-15
  • [Presentation] ショウジョウバエ視覚系ラミナ細胞におけるin vivo カルシウムイメージング2012

    • Author(s)
      森本 高子, 宮本 拓也, 鈴木 力憲, 青西亨, 宮川博義, 藤田 知世
    • Organizer
      第35回神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2012-09-19
  • [Presentation] ベイズ推定法による定量的カルシウム動態推定2012

    • Author(s)
      角田敬正, 織田善晃, 大森敏明, 井上雅司, 宮川博義, 岡田真人, 青西 亨
    • Organizer
      電子情報通信学会ニューロコンピューティング研究会
    • Place of Presentation
      玉川大学
    • Year and Date
      2012-03-16
  • [Presentation] 拡張カルマンフィルタによる樹状突起時空間的カルシウム動態の推定2011

    • Author(s)
      角田敬正, 織田善晃, 大森敏明, 井上雅司, 宮川博義, 岡田真人, 青西亨
    • Organizer
      日本神経回路学会 第21回全国大会
    • Place of Presentation
      沖縄科学技術大学院大学
    • Year and Date
      2011-12-17
  • [Presentation] Detection of cells from calcium imaging data by non-negative matrix factorization2011

    • Author(s)
      R. Maruyama, K. Maeda, H. Miyakawa, T. Aonishi
    • Organizer
      日本神経回路学会 第21回全国大会
    • Place of Presentation
      沖縄科学技術大学院大学
    • Year and Date
      2011-12-16
  • [Presentation] Automatic cell detection from calcium imaging data using nonnegative matrix factorization2011

    • Author(s)
      R. Maruyama, K. Maeda, H. Miyakawa, T. Aonishi
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington DC (USA)
    • Year and Date
      2011-11-13
  • [Presentation] Estimation of Dendritic Spatiotemporal Calcium Dynamics by Nonlinear State Space Modeling2011

    • Author(s)
      Takamasa Tsunoda, Yoshiaki Oda, Toshiaki Omori, Masato Okada, Masashi Inoue, Hiroyoshi Miyakawa and Toru Aonishi
    • Organizer
      JSST Annual Conference (JSST2011) International Conference on Modeling and Simulation Technology
    • Place of Presentation
      東海大学高輪キャンパス
    • Year and Date
      2011-10-23
  • [Presentation] The Effects of Noise in Visual Stimulus on Motion Detection in Drosophila Optomotor Response2011

    • Author(s)
      Yoshinori Suzuki, Toru Aonishi, Hiroyoshi Miyakawa, Takako Morimoto
    • Organizer
      Neurobiology of Drosophila
    • Place of Presentation
      Cold Spring Harbor Laboratory(New York)
    • Year and Date
      2011-10-04
  • [Book] Phase Response Curves in Neuroscience : Theory, Experiment, and Analysis2012

    • Author(s)
      Keisuke Ota and Toru Aonishi
    • Total Pages
      179-203
    • Publisher
      Springer Series in Computational Neuroscience
  • [Remarks]

    • URL

      http://www.acs.dis.titech.ac.jp

  • [Remarks]

    • URL

      http://www.researchgate.net/profile/Toru_Aonishi?ev=hdr_xprf

URL: 

Published: 2015-07-16  

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