2013 Fiscal Year Final Research Report
Influence of ambient neuromodulators on learning through hetero-GPCR interplay
| Project/Area Number |
23500384
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | University of Toyama |
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Principal Investigator |
TABATA Toshihide 富山大学, 大学院理工学研究部(工学), 准教授 (80303270)
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| Co-Investigator(Renkei-kenkyūsha) |
KAMIKUBO Yuji 順天堂大学, 医学部, 助教 (80509670)
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| Project Period (FY) |
2011 – 2013
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| Keywords | Ｇタンパク質 / シナプス可塑性 / ニューロン / 受容体 / 学習 / 小脳 / 生理学 / 神経科学 |
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| Research Abstract |
In cerebellar Purkinje cells, B-type gamma-aminobutyric acid receptor (GABAbR) and type-1 adenosine receptor (A1R) are suggested to modulate type-1 metabotropic glutamate receptor (mGluR1) whose intracellular signaling triggers induction of cerebellar long-term depression (LTD). Using a machine vision-based optokinetic reflex (OKR) measuring system, we found that in mice, cerebellar injection of a GABAbR agonist facilitated OKR adaptation, a cerebellar LTD-dependent learning. Moreover, using in-vitro preparations, we found that A1R interacted with mGluR1 via its C-terminus and that A1R activation suppressed the LTD of Purkinje cell's glutamate-responsiveness by lowering mGluR1's ligand-sensitivity in a G protein-independent manner. The hetero-G protein-coupled receptor interplay may influence central synaptic plasticity and learning.
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[Journal Article] The synaptic targeting of mGluR1 by its carboxyl-terminal domain is crucial for cerebellar function2014
Author(s)
Y. Ohtani, M. Miyata, K. Hashimoto, T. Tabata, Y. Kishimoto, M. Fukaya, D. Kase, H. Kassai, K. Nakao, T. Hirata, M. Watanabe, M. Kano, A. Aiba
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Journal Title
Journal of Neuroscience
Volume: 34(7)
Pages: 2702-2712
DOI
Peer Reviewed
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