2013 Fiscal Year Final Research Report
Nucleotide-induced glutamatergic subtype selection of newborn neurons
| Project/Area Number |
23500392
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Kyoto University |
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Principal Investigator |
TAKEI Yoshinori 京都大学, 薬学研究科(研究院), 助教 (30502455)
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| Project Period (FY) |
2011 – 2013
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| Keywords | シグナル伝達 / 発生、分化 / 脳、神経 / 神経科学 |
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| Research Abstract |
Glutamategic neurons are produced through life in the hippocampus. However, mechanism determining subtype selection of newborn neurons has not been elucidated. Here, we showed that extracellular nucleotides induced glutamatergic subtype markers in the newborn neurons. Pharmacological study indicated the receptor corresponding to the nucleotide-induced glutamagergic differentiation. Expression of the corresponding receptor was transiently augmented in the course of neuronal differentiation of mouse ES cells in vitro. The augmentation was coincident with the period when nucleotide can induce glutamatergic subtype markers. These results indicate that extracellular nucleotides can contribute to the glutamatergic subtype selection of newborn neurons.
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Research Products
(5 results)
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[Remarks] 朝日新聞(5月22日22面), 京都新聞(5月16日30面), 産経新聞(5月16日28面), 中日新聞(5月16日3面),日刊工業新聞(5月16日21面),日本経済新聞(5月16日42面), 毎日新聞(5月16日27面) および読売新聞(5月16日1面・33面)(新聞報道)
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