2013 Fiscal Year Final Research Report
Analysis of Interaction among Epigenetic Mechanisms during Sexual Differentiation of Brain
| Project/Area Number |
23500396
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
MATSUDA Ken Ichi 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (40315932)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 脳の性差 / 性分化 / エストロゲン / アンドロゲン / エピジェネティックス / ヒストンアセチル化 / ヒストン脱アセチル化 / DNAメチル化 |
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| Research Abstract |
Sexual differentiation of the brain can be considered as a process during which effects of sex steroid hormones during development are maintained into adulthood. Epigenetic regulation is emerging as an important mechanism of lasting effects of the hormonal milieu in the developing brain. Evidence has accumulated hat epigenetic regulation is involved in sexual differentiation of the brain. Epigenetic regulation occurs via different mechanisms, and interactions between histone modifications and DNA methylation have been suggested. There may be some synergistic and/or hierarchical interactions among the epigenetic modifications that control sexual differentiation of the brain. In this research, it was examined whether interactions among different epigenetic mechanisms are involved in sexual differentiation of the brain, and founded that the hierarchical order among epigenetics mechanisms (i.e., histone acetylation-deacetylation, and then DNA methylation) existed in its early process.
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