Neural basis of human decision-making; Analysis in de novo Parkinson disease patients by neuroeconomic task

2013 Fiscal Year Final Research Report

• Project/Area Number: 23500398
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: Keio University
• Principal Investigator: TAKAHASHI Kazushi 慶應義塾大学, 医学部, 講師(非常勤) (80236265)
• Co-Investigator(Renkei-kenkyūsha): TABUCHI Hajime 慶應義塾大学, 医学部, 講師 (10286578)
• Project Period (FY): 2011 – 2013
• Keywords: パーキンソン病 / 神経経済学 / 行動神経科学 / 意思決定 / 機能的MRI検査

Research Abstract

THE DISRUPTION OF VENTRAL STRIATUM AND AMYGDALA ACTIVITY TO FINANCIAL CUES IN NEVER-MEDICATED PARKINSON DISEASE PATIENTS.
Objectives: This study investigated the altered neural processes underlying behavioral responses in never-medicated PD patients by using a neuroecomonics task in conjunction with functional magnetic resonance imaging. Methods: The de novo PD patients (n = 9) and age matched healthy controls (n = 8) performed a modified monetary incentive delay task. Results: The activity of ventral striatum and amygdala to financial cues was reduced in untreated de novo PD patients. PD patients in the early stage might show the dual reduced brain activities, including the hypoactivity of ventral striatum constituting the brain reward system and the dysfunction of amygdala that may play a key role in loss aversion. In PD, the dysfunction in ventral striatum and amygdala may be present from onset, and represent a behavioral endophenotype, prior to dopaminergic treatment.

Research Products

• [Journal Article] パーキンソン病の初期診断Premotor phase の非運動症状 (2013)
  • Author(s): 高橋一司
  • Journal Title: 臨床神経 Volume: Vol.53, No.11 Pages: 974-976
  • DOI: 10.5692/clinicalneurol.53.974
• [Journal Article] Clinical features and varieties of non-motor fluctuations in Parkinson's disease : A Japanese multicenter study (2013)
  • Author(s): Seki M, Takahashi K, Uematsu D, Mihara B, Morita Y, Isozumi K, Ohta K, Muramatsu K, Shirai T, Nogawa S, Gotoh J, Yamaguchi K, Tomita Y, Yasutomi D, Nihei N, Iwasawa S, Suzuki N
  • Journal Title: Parkinsonism & Related Disord Volume: Vol.19, No.1 Pages: 104-108
  • DOI: 10.1016/j.parkreldis.2012.08.004
  • Peer Reviewed
• [Journal Article] REM Sleep Behavior Disorder in Japanese Patients with Parkinson's Disease : A Multicenter Study Using the REM Sleep Behavior Disorder Screening Questionnaire (2012)
  • Author(s): Nihei Y, Takahashi K, Koto A, Mihara B, Morita Y, Isozumi K, Ohta K, Muramatsu K, Gotoh J, Yamaguchi K, Tomita Y, Sato H, Seki M, Iwasawa Y, Suzuki N
  • Journal Title: Journal of Neurology Volume: Vol.259, No.8 Pages: 1606-1612
  • DOI: 10.1007/s00415-011-6386-1
  • Peer Reviewed
• [Presentation] Premotor symptoms in Parkinson's disease (2014)
  • Author(s): Takahashi K
  • Organizer: The 13th International Parkinsons disease Symposium in Takamatsu
  • Place of Presentation: 高松市
  • Year and Date: 2014-02-22
• [Presentation] シンポジウム【運動症状発症以前のパーキンソン病の診断は可能か?】非運動症状の組み合わせでパーキンソン病の発症は予測できるか? (2013)
  • Author(s): 高橋一司
  • Organizer: 第7回パーキンソン病・運動障害疾患コングレス(MDSJ)
  • Place of Presentation: 東京
  • Year and Date: 2013-10-11
• [Presentation] The disruption of ventral striatum and amygdala activity to financial cues in never-medicated Parkinson disease patients (2013)
  • Author(s): Kazushi Takahashi
  • Organizer: The 21th World Congress of Neurology
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2013-09-25
• [Presentation] シンポジウム【パーキンソン病の初期診断】Premotor phase の非運動症状 (2013)
  • Author(s): 高橋一司
  • Organizer: 第54回日本神経学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2013-05-29
• [Book] パーキンソン病 : インフォームドコンセントのための図説シリーズ (2013)
  • Author(s): 高橋一司, 他
  • Total Pages: 122-129
  • Publisher: 医薬ジャーナル社
• [Book] 今日の治療指針2012年(Volume54)パーキンソン病の内科的治療 (2012)
  • Author(s): 高橋一司, 他
  • Total Pages: 780-783
  • Publisher: 医学書院
• [Book] ガイドラインサポートハンドブックパーキンソン病 (2011)
  • Author(s): 高橋一司, 他
  • Total Pages: 158-180
  • Publisher: 医薬ジャーナル社