2013 Fiscal Year Final Research Report
Regulatory mechanism of circuit remodeling after nerve injury
| Project/Area Number |
23500400
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
MIYATA MARIKO 東京女子医科大学, 医学部, 教授 (70281631)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 視床 / 抑制系入力 / tonic GABA 受容体 / 内側毛帯線維 |
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| Research Abstract |
The rodent ventral posterior medial (VPm) nucleus receives an excitatory input via the medial lemniscal synapse. In addition, the VPm also receives nearly all of the inhibitory inputs from the thalamic reticular nucleus (TRN). We previously reported that the complete transection of the infraorbital nerve (ION)resulted in multiple innervation of medial lemniscal fibers onto a VPm neuron around 5 days after operation (POD5) . However, it remains still unclear the postoperative change of inhibitory inputs onto VPm neurons after the transection of ION. ION cutreduced the amplitude of evoked-inhibitory postsynaptic currents (eIPSCs).Interestingly, in contrast, tonic GABA currents onto VPm neurons rapidly increased by the transection of the ION at POD1. At POD7, tonic GABA currents also increased in VPm neurons, which had multiple lemniscal fibers by the transection of ION. Thus, inhibitory input change may interact with the remodeling of lemniscal fibers.
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[Journal Article] Synaptic targeting of mGluR1 by carboxyl-terminal domain is crucial for cerebellar function2014
Author(s)
Ohtani Yoshiaki, Miyata Mariko(Co first author), Hashimoto Kouichi, Tabata Toshihide, Kishimoto Yasushi, Fukaya Masahiro, Kase Daisuke, Kassai Hidetoshi, Nakao Kazuki, Hirata Tatsumi, Watanabe Masahiko, Kano Masanobu, and Aiba Atsu
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Journal Title
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume: 34(7)
Pages: 2702-2712
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