2013 Fiscal Year Final Research Report
Metabotropic Glutamate Receptor Subtype 7 in the Bed Nucleus of the Stria Terminalis is Essential for Aggression
| Project/Area Number |
23500415
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
MASUGI-TOKITA Miwako (馬杉 美和子) 京都府立医科大学, 医学(系)研究科(研究院), 助教 (10420712)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAMOTO Hirotaka 岡山大学, 大学院・自然科学研究科, 准教授 (20363971)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 分子神経生物学 / 攻撃行動 / 性行動 / グルタミン酸 |
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| Research Abstract |
Metabotropic glutamate receptor subtype 7 (mGluR7) is a member of group III mGluRs, which locates in the presynaptic active zones. Using a resident-intruder paradigm, we found a severe impairment of aggression in mGluR7 knockout (KO) mice. Since olfaction is known to be a critical component for aggressive behavior, we further employed an olfaction test and found altered urine preference in mGluR7 KO mice. Then, to clarify the olfactory processing, we analyzed c-Fos-immunoreactivity after exposure to urine, and found a remarkable reduction of neuronal activity in the bed nucleus of the stria terminalis (BNST) of mGluR7 KO mice. Finally, intra-BNST administration of the mGluR7-selective antagonist 6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazolo[4,5-c]pyridin-4(5H)-one (MMPIP) also impaired aggression. These results indicate that mGluR7 works as an enhancer of excitation in the BNST and is essential to evoke olfaction-based aggressive behavior.
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[Journal Article] Distinct cerebellar engrams in short-term and long-term motor learning2014
Author(s)
Wang W, Nakadate K, Masugi-Tokita M (W .W., K.N., M.M.-T., and F.S. contributed equally to this work), Shutoh F, Aziz W, Tarusawa E, Lorincz A, Molnár E, Kesaf S, Li YQ, Fukazawa Y, Nagao S, Shigemoto R
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Journal Title
Proc Natl Acad Sci USA
Volume: 111(1)
Pages: E188-93
DOI
Peer Reviewed
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