2013 Fiscal Year Final Research Report
Roles of granulovacuolar degeneration in neurodegenerative diseases
| Project/Area Number |
23500426
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Nerve anatomy/Neuropathology
|
|---|
| Research Institution | Gunma University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Kouichi 群馬大学, その他部局等, 名誉教授 (00124652)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 顆粒空胞変性 / 神経変性疾患 / 平野小体 |
|---|
| Research Abstract |
Abnormal protein accumulation is thought to be the cause of neuronal cell death at least in some neurodegenerative diseases. We hypothesized that ER stress-autophasy systems might be included in this disease mechanisms and the pivotal pathological structure is granulovacuolar degeneration. To study this hypothesis we carried out immunohistological examinations using postmortem brains.
In brains of multiple system atrophy, we observed increased expression of ER stress related proteins in granulovacuolar degeneration and also increased activation of lysosomal systems in microglia. In Alzheimer's brains, increased expression of a ubiquitin degradation system protein, called Smurf1 was detected in Hirano bodies.
|
-
-
[Journal Article] Cerebrospinal fluid levels of phosphorylated tau and Aβ1-38/Aβ1-40/Aβ1-42 in Alzheimer's disease with PS1 mutations2013
Author(s)
Ikeda M, Yonemura K, Kakuda S, Tashiro Y, Fujita Y, Takai E, Hashimoto Y, Makioka K, Furuta N, Ishiguro K, Maruki R, Yoshida J, Miyaguchi O, Tsukie T, Kuwano R, Yamazaki T, Yamaguchi H, Amari M, Takatama M, HarigayaY, Okamoto K
-
Journal Title
Amyloid
Volume: Vol.20
Pages: 107-112
DOI
Peer Reviewed
-
-
[Journal Article] fox-pigeon imitation test (YFPIT) for dementia in clinical practice2011
Author(s)
Yamaguchi H, Takahashi S, Kosaka K, Okamoto K, Yamazaki T, Ikeda M, Osawa M, Amari M, Harigaya Y, Awata S, Maki Y, Yamaguchi
-
Journal Title
Psychogeriatrics
Volume: Vol.11
Pages: 221-226
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
