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2013 Fiscal Year Final Research Report

Comprehensive study on dystonia pathology

Research Project

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Project/Area Number 23500428
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionThe University of Tokushima

Principal Investigator

GOTO Satoshi  徳島大学, ヘルスバイオサイエンス研究部, 特任教授 (50240916)

Co-Investigator(Kenkyū-buntansha) KAJI Ryuji  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (00214304)
Project Period (FY) 2011 – 2013
Keywordsジストニア / 神経病理 / 機能解剖 / 線条体
Research Abstract

In the mammalian striatum, there exist two functional subdivisions termed as striosome and matrix compartments. We have proposed a hypothesis that an imbalanced activities between the striosome and matrix compartments may cause movement disorders that include dystonia. During the last 3 years, we found a selective loss of dopamine D1 receptor D1R and Golf expression in the striosomes in a transgenic mouse model with dystonia, and suggest that a loss of D1Rmediated signaling in the striosomes may cause dystonia symptoms. Moreover, our pathological study on the autopsied brains showed the defects in the neuropeptide NPY system in the striatum of the patients with DYT3 dystonia. Since NPY has a protective role against glutamate receptor-mediated neurotoxicity and promotes striatal neurogenesis, this finding suggests that defects in the NPY system may underlie the genesis of progressive striatal generation that primarily occurs in the striosome compartment.

  • Research Products

    (30 results)

All 2014 2013 2012 2011

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (6 results) Book (9 results)

  • [Journal Article] A novel tyrosine kinase inhibitor AMN107 (nilotinib) normalizes striatal motor behaviors in a mouse model of Parkinson's disease2014

    • Author(s)
      Tanabe A, Yamamura Y, Kasahara J, Morigaki R, Kaji R, & Goto S
    • Journal Title

      Front Cell Neurosci

      Volume: 8:50 Pages: 1-10

    • DOI

      10.3389/fncel.2014.00050

    • Peer Reviewed
  • [Journal Article] Defects in the striatal neuropeptide Y system in X-linked dystonia-parkinsonism2013

    • Author(s)
      S. Goto, T. Kawarai, R. Morigaki, S. Okita, H. Koizumi, S. Nagahiro, E.L. Munoz, L.V. Lee & R. Kaji
    • Journal Title

      Brain

      Volume: 136(Pt5) Pages: 1555-1567

    • DOI

      10.1093/brain/awt084

    • Peer Reviewed
  • [Journal Article] Depression in X-linked dystonia-parkinsonism : a case-control study2013

    • Author(s)
      R. Morigaki, Nakataki, T. Kawarai, L.V . Lee, R.A. Teleg, M.D. Tabuena, H. Mure, W. Sako, P.M. Pasco, S. Nagahiro, J. Iga, T. Ohmori, S. Goto & R. Kaji
    • Journal Title

      Parkinsonism Relat Disord

      Volume: 19 Pages: 844-846

    • DOI

      10.1016/j.parkreldis.2013.04.027

    • Peer Reviewed
  • [Journal Article] Application of long-range polymerase chain reaction in the diagnosis of X-linked dystonia-parkinsonism2013

    • Author(s)
      T. Kawarai, P .M. Pasco, R.A. Teleg, M. Kamada, W. Sako, K. Shimozono, M. Mizuguchi, D. Tabuena, A. Orlacchio, Y. Izumi, S. Goto, L.V. Lee & R. Kaji
    • Journal Title

      Neurogenetics

      Volume: 14 Pages: 167-169

    • DOI

      10.1007/s10048-013-0357-x

    • Peer Reviewed
  • [Journal Article] Response of striosomal opioid signaling to dopamine depletion in 6-hydroxydopamine-lesioned rat model of Parkinson's disease : a potential compensatory role2013

    • Author(s)
      H. Koizumi, R. Morigaki, S. Okita, S. Nagahiro, R. Kaji, M. Nakagawa & S. Goto
    • Journal Title

      Front Cell Neurosci

      Volume: 7 Pages: e74

    • DOI

      10.3389/fncel.2013.00074

    • Peer Reviewed
  • [Journal Article] Dopamine signaling negatively regulates striatal phosphorylation of Cdk5 at tyrosine 15 in mice2013

    • Author(s)
      Y. Yamamura, R. Morigaki, J. Kasahara, H. Yokoyama, A. Tanabe, S. Okita, H. Koizumi, S. Nagahiro, R. Kaji & S. Goto
    • Journal Title

      Front Cell Neurosci

      Volume: 7 Pages: e12(1-10)

    • DOI

      10.3389/fncel.2013.00012

    • Peer Reviewed
  • [Journal Article] Behavioural and anatomical characterization of mutant mice with targeted deletion of D1 dopamine-receptor-expressing cells : response to acute morphine2013

    • Author(s)
      D. Babovic, L. Jiang, S. Goto, I. Gantois, G , Schutz, A.J. Lawrence, J.L. Waddington & J. Drago
    • Journal Title

      J Pharmacol Sci

      Volume: 121 Pages: 39-47

    • Peer Reviewed
  • [Journal Article] Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential2012

    • Author(s)
      Y. Kuroda, W. Sako, S. Goto, T. Sawada, D. Uchida, Y. Izumi, T. Takahashi, N. Kagawa, M. Matsumoto, M. Matsumoto, R. Takahashi, R. Kaji & T. Mitsui
    • Journal Title

      Hum Mol Genet

      Volume: 21 Pages: 991-1003

    • DOI

      10.1093/hmg/ddr530

    • Peer Reviewed
  • [Journal Article] Cell type-specific localization of optineurin in the striatal neurons of mice : implications for neuronal vulnerability in Huntington' s disease2012

    • Author(s)
      S. Okita, R. Morigaki, H. Koizumi, R. Kaji, S. Nagahiro & S. Goto
    • Journal Title

      Neuroscience

      Volume: 202 Pages: 363-370

    • DOI

      10.1016/j.neuroscience.2011

    • Peer Reviewed
  • [Journal Article] The TRK-fused gene is mutated in hereditary motor and sensory neuropathy with proximal dominant involvement2012

    • Author(s)
      H. Ishiura, W. Sako, M. Yoshida, T. Kawarai, O. Tanabe, J. Goto, Y. Takahashi, H. Date, J. Mitsui, B. Ahsan, Y. Ichikawa, A. Iwata, H. Yoshino, Y. Izumi, K. Fujita, K. Maeda, S. Goto, R. Kaji & S. Tsuji (他9名)
    • Journal Title

      Am J Hum Genet

      Volume: 91 Pages: 320-329

    • DOI

      10.1016/j.ajhg.2012.07.014

    • Peer Reviewed
  • [Journal Article] Generalized dystonia in a patient with a novel mutation in the GLUD1 gene2012

    • Author(s)
      R. Miyamoto, S. Goto, W. Sako, A. Miyashiro, I. Kim, F . Escande, M. Harada, R. Morigaki, K. Asanuma, Y. Mizobuchi, S. Nagahiro, Y. Izumi & R. Kaji
    • Journal Title

      Mov Disord

      Volume: 27 Pages: 1198-1199

    • DOI

      10.1002/mds.25081

    • Peer Reviewed
  • [Journal Article] Bilateral pallidal stimulation in primary Meige syndrome2011

    • Author(s)
      W. Sako, R. Morigaki, Y. Mizobuchi, T. Tsuzuki, H. Ima, Y. Ushio, S. Nagahiro, R. Kaji & S. Goto
    • Journal Title

      Parkinsonism Relat Disord

      Volume: 17 Pages: 123-125

    • DOI

      10.1016/j.parkreldis.2010.11.013

    • Peer Reviewed
  • [Journal Article] Identification and localization of a neuron-specific isoform of T AF1 in rat brain : implications for neuropathology of DYT3 dystonia2011

    • Author(s)
      W. Sako, R. Morigaki, R. Kaji, I. Tooyama, S. Okita, K. Kitazato, S. Nagahiro, A.M. Graybiel & S. Goto
    • Journal Title

      Neuroscience

      Volume: 189 Pages: 100-107

    • DOI

      10.1016/j.neuroscience.2011.05.031

    • Peer Reviewed
  • [Journal Article] Cyclin-dependent kinase 5 with phosphorylation of tyrosine 15 residue is enriched in striatal matrix compartment in adult mice2011

    • Author(s)
      R. Morigaki, W. Sako, S. Okita, J. Kasahara, H. Yokoyama, S. Ngahiro, R. Kaji & S. Goto
    • Journal Title

      Neuroscience

      Volume: 189 Pages: 25-31

    • DOI

      10.1016/j.neuroscience.2011.05.055

    • Peer Reviewed
  • [Journal Article] Brainstem and spinal cord motor neuron involvement with optineurin inclusions in proximal-dominant hereditary motor and sensory neuropathy2011

    • Author(s)
      K. Fujita, M. Yoshida, W. Sako, K. Maeda, Y. Hashizume, S. Goto, G . Sobue, T. Izumi & R. Kaji
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 82 Pages: 1402-1403

    • DOI

      10.1136/jnnp-2011-300783

    • Peer Reviewed
  • [Presentation] ジストニックストームにおける治療法の検討-4 例の自験例と文献的考察-2014

    • Author(s)
      牟礼英生, 小泉英貴, 森垣龍馬, 大北真哉, 梶龍兒, 永廣信治, 後藤恵
    • Organizer
      第53回日本定位・機能神経外科学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2014-02-08
  • [Presentation] X-linked dystonia-parkinsonism のニューロペプタイドY システム2014

    • Author(s)
      森垣龍馬, 瓦井俊孝, 小泉英貴, 牟礼英生, 大北真哉, 溝渕佳史, 永廣信治, 梶龍兒, 後藤惠
    • Organizer
      第53回日本定位・機能神経外科学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2014-02-08
  • [Presentation] 高インスリン血性高アンモニア血性症候群に合併した全身性ジストニアに対し脳深部刺激術を施行した1例2014

    • Author(s)
      大北真哉, 森垣龍馬, 牟礼英生, 宮本亮介, 山本伸昭, 溝渕佳史, 後藤惠, 梶龍治, 永廣信治
    • Organizer
      第53回日本定位・機能神経外科学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2014-02-07
  • [Presentation] ドパミンシグナルはマウス線条体サイクリン依存性キナーゼ5(Cdk5)のチロシン15 残基リン酸化を抑制的に制御する2013

    • Author(s)
      山村行生, 森垣龍馬, 笠原二郎, 横山宏典, 田邊彬恵, 大北真哉, 小泉英貴, 永廣信治, 梶龍兒, 後藤惠
    • Organizer
      Neuro2013
    • Place of Presentation
      京都国際会議場(京都府)
    • Year and Date
      20130620-23
  • [Presentation] TFG 変異による運動ニューロン死のメカニズム2013

    • Author(s)
      瓦井俊孝, 森田光哉, 森垣龍馬, 藤田浩司, 野寺裕之, 和泉唯信, 後藤惠, 中野今治, 梶龍兒
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      20130529-0601
  • [Presentation] ジストニアの病態生理 : 大脳基底核機能解剖2013

    • Author(s)
      後藤 惠
    • Organizer
      第54回日本神経学会学術大会シンポジウム S(4)-7 不随意運動の病態生理
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      20130529-0601
  • [Book] Deep brain stimulation for essential tremor. In : T. Itakura (ed.) Deep Brain Stimulation for Neurological Disorder-Theoretical Background and Clinical Application2014

    • Author(s)
      R. Morigaki & S. Goto
    • Publisher
      Springer
  • [Book] Current use of thalamic Vim stimulation in treating Parkinson's disease. In : A.Q. Rana (ed.). Parkinson's Disease2014

    • Author(s)
      N. Tani, R. Morigaki, R. Kaji & S. Goto
    • Publisher
      InTech Publisher
  • [Book] Deep brain stimulation for camptocormia associated with Parkinson's disease. In : A.Q. Rana (ed.). Parkinson's Disease2014

    • Author(s)
      N. Tani, R. Kaji & S. Goto
    • Publisher
      InTech Publisher
  • [Book] DYT3 ジストニア (X-limked dystonia-parkinsonism : XDP, Lubag 症候群). 神経症候群II2014

    • Author(s)
      後藤 惠
    • Total Pages
      271-275
    • Publisher
      日本臨床, 東京
  • [Book] ジストニアの病理・機能解剖. ジストニアのすべて2013

    • Author(s)
      後藤 惠
    • Total Pages
      39-47
    • Publisher
      診断と治療社, 東京
  • [Book] ジストニアの分子病態- X-linked recessive dystonia-parkinsonism (XDP)を中心として. ジストニア20122012

    • Author(s)
      梶 龍兒, 後藤 惠 (他5名)
    • Total Pages
      185-193
    • Publisher
      中外医学社, 東京
  • [Book] Current use of thalamic surgeries for treating movement disorders. In : J.L. Song et al. (eds.). Thalamus : Anatomy, Functions and Disorders2011

    • Author(s)
      R. Morigaki, S. Nagahiro, R. Kaji & S. Goto
    • Total Pages
      1-32
    • Publisher
      Nova Science Publishers, New York
  • [Book] Thalamic deep brain stimulation for Parkinson's disease. In : A.Q. Rana (ed.). Diagnosis and treatment of Parkinson's disease2011

    • Author(s)
      R. Morigaki, S. Nagahiro, R. Kaji & S. Goto
    • Total Pages
      233-252
    • Publisher
      InTech Publisher, Croatia
  • [Book] パーキンソン病のDBS治療2011

    • Author(s)
      後藤 惠
    • Total Pages
      2435-2440
    • Publisher
      総合臨床

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Published: 2015-07-16  

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