2013 Fiscal Year Final Research Report
Neuropathologic analysis of small vessel diseases of the cerebral white matter in association with sporadic and hereditary dementia
| Project/Area Number |
23500435
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
TAKAO MASAKI 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (50245487)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Yuko 独立行政法人国立精神・神経医療研究センター, 臨床検査部, 室長 (60344066)
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| Research Collaborator |
ITO S 虎ノ門病院, 病理, 医師
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| Project Period (FY) |
2011 – 2013
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| Keywords | 脳・神経 / 病理学 / 脳血管疾患 / 認知症 / 神経科学 / 長寿命化 / 生体材料 |
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| Research Abstract |
The aim of the present study is to clarify the role of small vessel diseases in the cerebral white matter in dementia individuals. We carried out clinical and neuropathologic studies of 1) CARASIL cases, 2) mildly demented (CDR=0.5) individuals and 3) morphological analysis of small vessels in the cerebral white matter and putamen. The small vessels of CARASIL showed multilayers of elastic membranes and thinning of tunica media. Those findings were different from those of usual atherosclerotic changes. Frequency of cerebrovascular diseases was relatively high in mildly demented cases. However, the rate of cerebrovascular diseases decreased with increase of age. The lumen of small vessels in the cerebral white matter decreased with increasing grade of Braak stages of neurofibrillary tangles. Our multidisciplinary approaches suggest that small vessel diseases are important to understand dementia cases.
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[Journal Article] Imaging spectrum of sporadic cerebral amyloid angiopathy : multifaceted features of a single pathological condition2014
Author(s)
Sakurai K, Tokumaru AM, Nakatsuka T, Murayama S, Hasebe S, Imabayashi E, Kanemaru K, Takao M, Hatsuta H, Ishii K, Saito Y, Shibamoto Y, Matsukawa N, Chikui E, Terada H
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Journal Title
Insights Imaging
Volume: (in press)
URL
Peer Reviewed
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[Journal Article] Molecular analysis and biochemical classification of TDP-43 proteinopathy2013
Author(s)
Tsuji H, Arai T, Kametani F, Nonaka T, Yamashita M, Suzukake M, Hosokawa M, Yoshida M, Hatsuta H, Takao M, Saito Y, Murayama S, Akiyama H, Hasegawa M, Mann DM, Tamaoka A
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Journal Title
Brain
Volume: 135
Pages: 3380-91
DOI
Peer Reviewed
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[Journal Article] Neuropathologic analysis of Lewy-related α-synucleinopathy in olfactory mucosa2013
Author(s)
Funabe S, Takao M, Saito Y, Hatsuta H, Sugiyama M, Ito S, Kanemaru K, Sawabe M, Arai T, Mochizuki H, Hattori N, Murayama S
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Journal Title
Neuropathology
Volume: 33
Pages: 47-58
DOI
Peer Reviewed
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[Journal Article] Reduced brain-derived neurotrophic factor (BDNF) mRNA expression and presence of BDNF- immunoreactive granules in the spinocerebellar ataxia type 6 (SCA6) cerebellum2012
Author(s)
Takahashi M, Ishikawa K, Sato N, Obayashi M, Niimi Y, Ishiguro T, Yamada M, Toyoshima Y, Takahashi H, Kato T, Takao M, Murayama S, Mori O, Eishi Y, Mizusawa H
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Journal Title
Neuropathology
Volume: 32
Pages: 595-603
DOI
Peer Reviewed
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[Presentation] ブレインバンク研究班 ブレインバンク(BB)に関する調査研究(文科省脳科学研究戦略推進プログラム脳基盤研究)の結果概要報告2013
Author(s)
有馬邦正, 武田伸一, 丸山英二, 松下一章, 木原章子, 服部功太郎, 柿田明美, 豊島靖子, 村山繁雄, 高尾昌樹, 富田博秋, 手嶋豊, 磯部哲, 佐藤雄一郎, 伏木信次, 辻村貴子, 佐藤啓造, 丹羽真一, 武藤香織, 井上悠輔, 辰井聡子, 伊藤雅之, 黒木規臣, 石川 正憲, 齊藤祐子, Lin Crystal
Organizer
第54回日本神経病理学会総会学術研究会
Year and Date
20130424-26
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[Presentation] New Observations in Gerstmann-Straussler-Scheinker Disease Associated with the PRNP A117V Mutation2012
Author(s)
Takao M, Spina S, Murrell J, Epperson F, Glazier B, Farlow M, Unverzagt F, Saykin S, Yoder K, Risacher S, Kepe V, Barrio J
Organizer
The 88th Annual meeting of the American Association of Neuropathologists, Inc
Year and Date
20120621-24
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[Presentation] Clinical and Neuropathologic Heterogeneity in PSEN1 A431E2012
Author(s)
Murrell J, Mehta R, Bigio E, Cairns N, Cochran E, Gitelman D, Head E, Leverenz J, Poon W, Takao M, Weintraub S, Ringman J, Ghetti B
Organizer
The 88th Annual meeting of the American Association of Neuropathologists, Inc
Year and Date
20120621-24
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