The role of prostaglandins in myelination and axonal protection by oligodendrocytes

2013 Fiscal Year Final Research Report

• Project/Area Number: 23500436
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Kagawa University (2013); Institute for Developmental Research, Aichi Human Service Center (2011-2012)
• Principal Investigator: CHIBA Yoichi 香川大学, 医学部, 講師 (30372113)
• Co-Investigator(Renkei-kenkyūsha): WATANABE Kikudo 甲子園大学, 栄養学部, 教授 (90211672) ; MIURA Koshiro 川崎医科大学, 医学部, 講師 (30284243) ; SHIMADA Atsuyoshi 愛知県心身障害者コロニー発達障害研究所, 病理学部, 室長 (50311444)
• Project Period (FY): 2011 – 2013
• Keywords: オリゴデンドロサイト / プロスタグランジンF2alpha

Research Abstract

Physiological roles of prostaglandin (PG) F2alpha in central nervous system have not been elucidated. We studied the function of PG2alpha in oligodendrocyte-lineage cells, since our previous study revealed oligodendroglial localization of prostamide/PGF synthase, a major PGF2alpha-producing enzyme in mouse central nervous system. We confirmed expression of prostamide/PGF synthase, production of PGF2alpha, and an increase in intracellular calcium concentration in response to exogenous PGF2alpha, in oligodendrocytes. PGF2alpha seemed to be essential for survival of oligodendrocyte-lineage cells in their early development, since oigodendrocyte precursors from prostamide/PGF synthase-knockout mice were not able to survive without PGF2alpha supplementation. In contrast, oligodendrocyte-lineage cells from knockout mice showed normal maturation in response to differentiation stimuli.

Research Products

• [Journal Article] Niemann-Pick disease type C1 predominantly involving the frontotemporal region, with cortical and brainstem Lewy bodies : An autopsy case (2014)
  • Author(s): Chiba Y, Komori H, Takei S, Hasegawa-Ishii S, Kawamura N, Adachi K, Nanba E, Hosokawa M, Enokido Y, Kouchi Z, Yoshida F, Shimada A
  • Journal Title: Neuropathology Volume: 34(1) Pages: 49-57
  • DOI: 10.1111/neup.12047
  • Peer Reviewed
• [Journal Article] Excitotoxicity-induced immediate surge in hippocampal prostanoid production has latent effects that promote chronic progressive neuronal death (2013)
  • Author(s): Yoshikawa K, Kita Y, Furukawa A, Kawamura N, Hasegawa-Ishii S, Chiba Y, Takei S, Maruyama K, Shimizu T, Shimada A
  • Journal Title: Prostaglandins Leukot Essent Fatty Acids Volume: 88 Pages: 373-381
  • DOI: 10.1016/j.plefa.2013.02.007
  • Peer Reviewed
• [Journal Article] Immunohistochemical demonstration of increased prostaglandin F2α levels in the rat hippocampus following kainic acid-induced seizures (2012)
  • Author(s): Takei S, Hasegawa-Ishii S, Uekawa A, Chiba Y, Umegaki H, Hosokawa M, Woodward DF, Watanabe K, Shimada A
  • Journal Title: Neuroscience Volume: 218 Pages: 295-304
  • DOI: 10/1016/j.neuroscience.2012.05.013
  • Peer Reviewed
• [Journal Article] Immunohistochemical localization of aggresomal proteins in glial cytoplasmic inclusions in multiple system atrophy (2012)
  • Author(s): Chiba Y, Takei S, Kawamura N, Kawaguchi Y, Sasaki K, Hasegawa-Ishii S, Furukawa A, Hosokawa M, Shimada A
  • Journal Title: Neuropathol Appl Neurobiol Volume: 38 Pages: 559-571
  • DOI: 10.1111/j.1365-2990.2011.01229.x
  • Peer Reviewed
• [Presentation] 脳と免疫系の接点としての脈絡叢間質および付着部における細胞動態とサイトカイン発現 (2013)
  • Author(s): 石井さなえ, 島田厚良, 稲葉宗夫, 李銘, 石明, 河村則子, 武井史郎, 千葉陽一, 細川昌則, 池原進
  • Organizer: 第54回日本神経病理学会
  • Place of Presentation: 東京都
  • Year and Date: 2013-04-25
• [Presentation] Immunohistochemical demonstration of enhanced prostaglandin F2a production following kainic acid-induced seizures in rat hippocampus (2012)
  • Author(s): Takei S, Hasegawa-Ishii S, Uekawa A, Chiba Y, Umegaki H, Hosokawa M, Woodward DF, Watanabe K, Shimada A
  • Organizer: 14th International Congress of Histochemistry and Cytochemistry
  • Place of Presentation: Kyoto
  • Year and Date: 2012-08-29
• [Presentation] 前頭側頭葉優位の脳萎縮を呈した若年型Niemann-Pick病C 型の一剖検例 (2012)
  • Author(s): 千葉陽一, 小森拓, 吉田太, 足立香織, 難波栄二, 武井史郎, 石井さなえ, 河内全, 榎戸靖, 細川昌則, 島田厚良
  • Organizer: 第53回日本神経病理学会
  • Place of Presentation: 新潟市
  • Year and Date: 2012-06-30
• [Presentation] 老化促進モデルマウスにみられる骨髄由来細胞の脳実質へのリクルートの亢進 (2012)
  • Author(s): 島田厚良, 石井さなえ, 稲葉宗夫, 李銘, 石明, 河村則子, 武井史郎, 千葉陽一, 榎戸靖, 河内全, 細川昌則, 池原進
  • Organizer: 第53回日本神経病理学会
  • Place of Presentation: 新潟市
  • Year and Date: 2012-06-30
• [Presentation] Immunohistochemical demonstration of enhanced prostaglandin F2α production following kainic acid-induced seizures in rat hippocampus (2011)
  • Author(s): Takei S, Hasegawa-Ishii S, Uekawa A, Furukawa A, Chiba Y, Kawamura N, Hosokawa M, Woodward DF, Watanabe K, Shimada A
  • Organizer: 12th International Conference on Bioactive Lipids in Cancer, Inflammation, and Related Diseases
  • Place of Presentation: Seattle, USA
  • Year and Date: 2011-09-19
• [Presentation] カイニン酸誘導てんかん発作に伴う海馬プロスタグランジンF_<2α>産生更新の免疫組織学的解析 (2011)
  • Author(s): 武井史郎, 石井さなえ, 上川篤志, 千葉陽一, 河村則子, Woodward DF, 渡部紀久子, 島田厚良
  • Organizer: 第52回日本神経病理学会
  • Place of Presentation: 京都市
  • Year and Date: 2011-06-04