2013 Fiscal Year Final Research Report
Recovery from spinal cord injury in the chronic phase -the mechanism of denosomin, a novel compound with multiactivities-
| Project/Area Number |
23500439
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | University of Toyama |
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Principal Investigator |
TOHDA Chihiro 富山大学, 和漢医薬学総合研究所, 准教授 (10272931)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUYA Yuji 富山大学, 大学院・医学薬学研究部(薬学), 教授 (50255858)
KUBOYAMA Tomoharu 富山大学, 和漢医薬学総合研究所, 助教 (10415151)
TESHIGAWARA Kiyoshi 岡山大学, 医歯(薬)学総合研究科, 助教 (40403737)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 脊髄損傷 / 軸索伸展 / アストロサイト / vimentin / IGF1受容体 / DARTS法 |
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| Research Abstract |
A novel compound, Denosomin, improved hindlimb motor dysfunction and axonal growth, especially in the 5-hydroxytryptamine (5-HT)-positive tracts across the scar and increased the density of astrocytes. Denosomin increased astrocyte proliferation, inhibited astrocytic death and increased the expression and secretion of vimentin in cultured astrocytes. Furthermore, vimentin treatment increased axonal outgrowth in cultured neurons, even in the presence of inhibitory CSPG. Vimentin-expressing astrocytes increased inside of the glial scars of SCI mice administered Denosomin, and 5-HT-positive axonal growth occurred in a vimentin-associated manner. We firstly found that vimentin stimulated directly IGF1 receptors on neurons and the signaling elicited the axonal growth.
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[Presentation] 「伝統医薬データベース」の構築2011
Author(s)
柴原直利, 東田千尋, Zhu Shu, 櫻井宏明, 数馬恒平, 山本武, 小泉桂一, 紺野勝弘, 門脇真, 小松かつ子
Organizer
第28回和漢医薬学会学術大会
Place of Presentation
富山
Year and Date
20110827-28
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