2013 Fiscal Year Final Research Report
Biological functional analysis of novel axon guidance molecule LOTUS
| Project/Area Number |
23500452
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Yokohama City University |
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Principal Investigator |
TAKEI Kohtaro 横浜市立大学, 生命医科学研究科, 教授 (40202163)
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| Co-Investigator(Renkei-kenkyūsha) |
GOSHIMA Yoshio 横浜市立大学, 医学研究科, 教授 (00153750)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 神経回路形成 / 神経発生 / 軸索伸長 / 神経再生 |
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| Research Abstract |
In developing lateral olfactory tract (LOT) in mouse embryos, axonal branch was increased in LOTUS-deficient mice, whereas the axonal branch was decreased in NgR1-deficient mice. Furthermore, the axonal branch was also decreased in their double knocking-out mice, suggesting that Nogo-NgR1 interaction may induce axonal branching of LOT.
On the other hand, doublecortin-positive migrating pyramidal neurons were found in inside area of dentate gylus of hippocampus in LOTUS-deficient mice when compared with the wild type mice, suggesting that LOTUS may be involved in neuronal migration in developing hippocampus
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Yamashita, N., Usui, H., Nakamura, F., Chen, S., Sasaki, Y., Hida, T., Suto, F., Taniguchi, M., Takei, K., Goshima, Y
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Pages: 3424
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Volume: 73(3)
Pages: 230-246
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[Journal Article] Localized role of CRMP1 and CRMP2 in neurite outgrowth and growth cone steering2012
Author(s)
Higurashi, M., Iketani, M., Takei, K., Yamashita, N., Aoki, R., Kawahara, N., Goshima, Y
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Journal Title
Developmental Neurobiology
Volume: 72
Pages: 1528-1540
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Peer Reviewed
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[Journal Article] The carboxyl-terminal region of Crtac1b/LOTUS acts as a functional domain in endogenous antagonism to Nogo receptor-12012
Author(s)
Kurihara, Y., Arie, Y., Iketani, M., Ito, H., Nishiyama, K., Sato, Y., Nakamura, F., Mizuki, N., Goshima, Y., Takei, K
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Journal Title
Biochemical and Biophysical Research Communications
Volume: 418
Pages: 390-395
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[Journal Article] Cartilage acidic protein-1B (LOTUS), an endogenous Nogo receptor antagonist for axon tract formation2011
Author(s)
Sato, Y., Iketani, M., Kurihara, Y., Yamaguchi, M., Yamashita, N., Nakamura, F., Arie, Y., Kawasaki, T., Hirata, T., Abe, T., Kiyonari, H., Strittmatter, S.M., Goshima, Y., and Takei, K
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Science
Volume: 333
Pages: 769-773
DOI
Peer Reviewed
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