2013 Fiscal Year Final Research Report
Pathomechanisms of anti-NMDA receptor encephalitis
| Project/Area Number |
23500455
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
TANAKA Keiko 金沢医科大学, 医学部, 教授 (30217020)
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| Co-Investigator(Renkei-kenkyūsha) |
KATO Nobuo 金沢医科大学, 医学部, 教授 (10152729)
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| Project Period (FY) |
2011 – 2013
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| Keywords | グルタミン酸受容体 / NMDA受容体 / 辺縁系脳炎 / 長期増強誘導 / 海馬細胞 / 記銘力障害 |
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| Research Abstract |
The roles of anti-N-methyl-D-aspartate receptor (NMDAR) antibodies from patients with NMDAR encephalitis on their neurological symptom were examined. The major symptom of NMDAR encephalitis is known as amnesia together with convulsions and other psychiatric symptoms. To reproduce these symptoms, we examined behavior of mice exposed chronically to the cerebrospinal fluid (CSF) from patients and found that mice injected with the CSF exhibited learning impairment. However, their brain tissues did not exhibit inflammatory cell infiltration, neuronal loss, or glial proliferation, and there was no increase in inflammatory cytokines. Thus, for the first time, we showed that the CSF from NMDAR encephalitis patients disturbed the memory function directly in mice. These effects were considered to be functional and without neuronal tissue destruction, which is compatible with the favorable outcome of this disease.
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Research Products
(29 results)
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[Journal Article] Immunopathological significance of ovarian teratoma in patients with anti-N-methyl-D-aspartate receptor encephalitis2014
Author(s)
Tabata, E. Masuda, M. Eriguchi, M. Yokoyama, M. Takahashi, Y. Tanaka, K. Yukitake, M, Horikawa, E. Hara, H
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Journal Title
Eur Neurol
Volume: 71
Pages: 42-48
DOI
Peer Reviewed
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[Journal Article] Details of treatment-related difficulties in men with anti-N-Methy-D-Aspartate receptor encephalitis2013
Author(s)
Sakamoto H, Hirano M, Samukawa M, Ueno S, Maekura S, Fujimura H, Kuwahara M, Hamada Y, Isono C, Tanaka K, Kusunoki S, Nakamura Y
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Journal Title
Eur Neurol
Volume: 69
Pages: 21-26
DOI
Peer Reviewed
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[Journal Article] Anti-NMDA-receptor antibody detected in encephalitis, schizophrenia, and narcolepsy with psychotic features2012
Author(s)
K Tsutsui, T Kanbayashi, K Tanaka, S Boku, W Ito, J Tokunaga, A Mori, Y Hishikawa, T Shimizu, S Nishino
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Journal Title
BMC Psychiatry
Volume: 12
Pages: 37
DOI
Peer Reviewed
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[Journal Article] Proteasome assembly defect due due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome2011
Author(s)
K Arima, A Kinoshita, H Mishima, N Kanazawa, T Kaneko, T Mizushima, K Ichinose, H Nakamura, A Tsujino, A Kawakami, M Matsunaka, S Kasagi, S Kawano, S Kumagai, K Ohmura, T Mimori, M Hirano, S Ueno, K Tanaka, M Tanaka, I Toyoshima, H Sugino, A Yamakawa, K Tanaka, N Niikawa, F Furukawa, S Murata, K Eguchi, H Ida, K Yoshiura
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Journal Title
Proc Natl Acad Sci USA
Volume: 108 ( 36 )
Pages: 14914-14919
DOI
Peer Reviewed
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