2013 Fiscal Year Final Research Report
Regulation of extinction of emotional memory by amygdaloid neural circuits
| Project/Area Number |
23500462
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Gunma University |
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Principal Investigator |
MIWA Hideki 群馬大学, 医学(系)研究科(研究院), 助教 (80468488)
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| Co-Investigator(Renkei-kenkyūsha) |
YANAGAWA Yuchio 群馬大学, 大学院・医学系研究科, 教授 (90202366)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 扁桃体 / GABA作動性ニューロン / Ca2+結合タンパク質 / 神経ペプチド / 情動 / 記憶 / 消去 |
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| Research Abstract |
Using vesicular GABA transporter (VGAT)-Venus transgenic mice, in which GABAergic neurons are labeled with the Venus fluorescent protein, the immunohistochemical characterization of GABAergic neurons in the amygdala was performed. As a result, nerve terminal-like signals of somatostatin (SST) and vasoactive intestinal peptide (VIP) in the central nucleus of the amygdala were observed. These results suggest that SST and VIP have unique roles in regulation of extinction of fear memory.
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