2013 Fiscal Year Final Research Report
Modulation of the amygdala synaptic neurotransmission that controls fear memory extinction
| Project/Area Number |
23500474
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
SEKIGUCHI Masayuki 独立行政法人国立精神・神経医療研究センター, 神経研究所 疾病研究第四部, 室長 (80260339)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 記憶 / 恐怖情動 / 不飽和脂肪酸 / カンナビノイド / 幼若期 / ストレスホルモン / シナプス / 精神・神経疾患 |
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| Research Abstract |
Fear memory is critical for survival, but uncontrollable augmentation of this implicit memory sometimes occurs in particular psychiatric and neurological disorders. The aim of the present study was to elucidate the mechanisms that control fear memory using mice.
As a result, we have found followings. (1) Fear memory is influenced by the balance of dietary polyunsaturated fatty acids via endocannabinoid neurotransmission. (2) Neonatal stress hormone (corticosterone) exposure suppresses adolescent fear memory extinction.
Identification of the biological system that plays a modulatory role in fear memory is fundamental to understanding the adjustment of this memory process. It is expected that elucidation of the control mechanisms aids in developing new treatment for disorders in which fear is a contributory factor.
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[Journal Article] β-Lactotensin derived from bovine β-lactoglobulin exhibits anxiolytic-like activity as an agonist for neurotensin NTS_2 receptor via activation of dopamine D_1 receptor in mice2011
Author(s)
Hou I-C, Suzuki C, Kanegawa N, Oda A, Yamada A, Yoshikawa M, Yamada D, Sekiguchi M, Wada E, Wada K, Ohinata K
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Journal Title
J Neurochem
Volume: 119
Pages: 785-90
URL
Peer Reviewed
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[Remarks] 新聞報道 : 1. 2013年 6月 19日讀賣新聞(夕刊)「青魚のDHA 怖い記憶緩和」
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[Remarks] 2. 2014年 3月 27日日刊工業新聞「脂肪酸摂取バランス不安症予防のカギ」
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[Remarks] 3. 2014年 3月 31日日経産業新聞「恐怖の記憶食事で差」
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