2013 Fiscal Year Final Research Report
Analysis of physiological functions of novel endothelial-enriched genes
| Project/Area Number |
23500488
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Shiga University of Medical Science (2013)
University of Tsukuba (2011-2012) |
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Principal Investigator |
EMA Masatsugu 滋賀医科大学, 動物生命科学研究センター, 教授 (60359578)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Satoru 筑波大学, 医学医療系, 教授 (50271896)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 血管新生 |
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| Research Abstract |
Blood vessels are therapeutic targets for cancer, ischemic diseases and diabetes-related diseases. Therefore, understanding the process of angiogenesis is important for not only intellectual but potentially development of medicine for such diseases. A novel Rho-related gene, RhoJ was investigated for its physiological function by knocking out. The RhoJ KO exhibited retarded angiogenesis in the retina. Since the retina showed empty sleeves, regression seems to be one of causes for the retarded angiogenesis.
Flk1-GFP :: Flt1-tdsRed BAC Tg mice were created to monitor the endogenous expression of Flk1 and Flt1. Based on the expression of Flk1-GFP and Flt1-tdsRed, Flk1 and Flt1 are expressed in micro capillaries and mid/major endothelial cells, respectively.
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Research Products
(15 results)
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[Journal Article] C1galt1-deficient mice exhibit thrombocytopenia due to abnormal terminal differentiation of megakaryocytes2013
Author(s)
Kudo T, Sato T, Hagiwara K, Kozuma Y, Yamaguchi T, Ikehara Y, Hamada M, Matsumoto K, Ema M, Murata S, Ohkohchi N, Narimatsu H, Takahashi S
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Journal Title
Blood
Volume: 122
Pages: 1649-1657
Peer Reviewed
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[Journal Article] Klf9 is necessary and sufficient for Purkinje cell survival in organotypic culture2013
Author(s)
Lebrun C., Avci HX., Wehrlé R., Doulazmi M., Jaudon F., Morel MP., Rivals I., Ema M., Schmidt S., Sotelo C., Vodjdani G., Dusart I
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Journal Title
Mol Cell Neurosci
Volume: 54
Pages: 9-21
Peer Reviewed
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[Journal Article] Delayed cutaneous wound healing in Fam129b/Minerva-deficient mice2012
Author(s)
Oishi H, Itoh S, Matsumoto K, Ishitobi H, Suzuki R, Ema M, Kojima T, Uchida K, Kato M, Miyata T, Takahashi S
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Journal Title
J. Biochem
Volume: 152
Pages: 549-555
Peer Reviewed
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[Journal Article] Thyroid hormone triggers the developmental loss of axonal regenerative capacity via thyroid hormone receptor α1 and kruppel-like factor 9 in Purkinje cells2012
Author(s)
Avci HX., Lebrun C., Wehrlé R., Doulazmi M., Chatonnet F., Morel MP., Ema M., Vodjdani G., Sotelo C., Flamant F., Dusart I
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Journal Title
Proc Natl Acad Sci USA
Volume: 109
Pages: 14206-14211
Peer Reviewed
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[Journal Article] Genome-wide identification of endothelial cell-enriched genes in the mouse embryo
Author(s)
Takase H., Matsumoto K., Yamadera R., Kubota Y., Otsu A., Suzuki R., Ishitobi H., Mochizuki H., Kojima T., Takano S., Uchida K., Takahashi S., Ema M
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Journal Title
Blood
Volume: 120
Pages: 914-923
Peer Reviewed
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[Presentation] Origin of cardiovascular cells and heart development controlled by VEGF-Flk1 signaling2014
Author(s)
Masatsugu Ema, Ayaka Otsu, Takuya Azami, Masanori Hirashima , Kazuko Koshiba-Takeuchi , Jun Takeuchi , Masabumi Shibuya, Janet Rossant, Satoru Takahashi, Tomomi Nishie
Organizer
第91回生理学会大会, シンポジウム講演
Place of Presentation
鹿児島
Year and Date
20140000
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