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2013 Fiscal Year Final Research Report

Analysis of physiological functions of novel endothelial-enriched genes

Research Project

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Project/Area Number 23500488
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Laboratory animal science
Research InstitutionShiga University of Medical Science (2013)
University of Tsukuba (2011-2012)

Principal Investigator

EMA Masatsugu  滋賀医科大学, 動物生命科学研究センター, 教授 (60359578)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Satoru  筑波大学, 医学医療系, 教授 (50271896)
Project Period (FY) 2011 – 2013
Keywords血管新生
Research Abstract

Blood vessels are therapeutic targets for cancer, ischemic diseases and diabetes-related diseases. Therefore, understanding the process of angiogenesis is important for not only intellectual but potentially development of medicine for such diseases. A novel Rho-related gene, RhoJ was investigated for its physiological function by knocking out. The RhoJ KO exhibited retarded angiogenesis in the retina. Since the retina showed empty sleeves, regression seems to be one of causes for the retarded angiogenesis.
Flk1-GFP :: Flt1-tdsRed BAC Tg mice were created to monitor the endogenous expression of Flk1 and Flt1. Based on the expression of Flk1-GFP and Flt1-tdsRed, Flk1 and Flt1 are expressed in micro capillaries and mid/major endothelial cells, respectively.

  • Research Products

    (15 results)

All 2014 2013 2012 2011 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (6 results) Book (1 results)

  • [Journal Article] C1galt1-deficient mice exhibit thrombocytopenia due to abnormal terminal differentiation of megakaryocytes2013

    • Author(s)
      Kudo T, Sato T, Hagiwara K, Kozuma Y, Yamaguchi T, Ikehara Y, Hamada M, Matsumoto K, Ema M, Murata S, Ohkohchi N, Narimatsu H, Takahashi S
    • Journal Title

      Blood

      Volume: 122 Pages: 1649-1657

    • Peer Reviewed
  • [Journal Article] Klf9 is necessary and sufficient for Purkinje cell survival in organotypic culture2013

    • Author(s)
      Lebrun C., Avci HX., Wehrlé R., Doulazmi M., Jaudon F., Morel MP., Rivals I., Ema M., Schmidt S., Sotelo C., Vodjdani G., Dusart I
    • Journal Title

      Mol Cell Neurosci

      Volume: 54 Pages: 9-21

    • Peer Reviewed
  • [Journal Article] Bioluminescence imaging of β cells and intrahepatic insulin gene activity under normal and pathological conditions2013

    • Author(s)
      Katsumata T, Oishi H, Sekiguchi Y, Nagasaki H, Daassi D, Tai PH, Ema M, Kudo T, Takahashi S
    • Journal Title

      PLoS One

      Volume: 8 Pages: e60411

    • Peer Reviewed
  • [Journal Article] Delayed cutaneous wound healing in Fam129b/Minerva-deficient mice2012

    • Author(s)
      Oishi H, Itoh S, Matsumoto K, Ishitobi H, Suzuki R, Ema M, Kojima T, Uchida K, Kato M, Miyata T, Takahashi S
    • Journal Title

      J. Biochem

      Volume: 152 Pages: 549-555

    • Peer Reviewed
  • [Journal Article] Flt1 and Flk1 mediate regulation of intraocular pressure and their double heterozygosity causes the buphthalmia in mice2012

    • Author(s)
      Sano K., Katsuta O., Shirae S., Kubota Y., Ema M., Suda T., Nakamura M., Hirashima M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 420 Pages: 422-427

    • Peer Reviewed
  • [Journal Article] Thyroid hormone triggers the developmental loss of axonal regenerative capacity via thyroid hormone receptor α1 and kruppel-like factor 9 in Purkinje cells2012

    • Author(s)
      Avci HX., Lebrun C., Wehrlé R., Doulazmi M., Chatonnet F., Morel MP., Ema M., Vodjdani G., Sotelo C., Flamant F., Dusart I
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 109 Pages: 14206-14211

    • Peer Reviewed
  • [Journal Article] Study of normal and pathological blood vessel morphogenesis in Flt1-tdsRed BAC Tg mice2012

    • Author(s)
      Matsumoto K., Azami T., Otsu A., Takase H., Ishitobi H., Tanaka J., Miwa Y., Takahashi S., Ema M
    • Journal Title

      Genesis

      Volume: 50 Pages: 561-571

    • Peer Reviewed
  • [Journal Article] Genome-wide identification of endothelial cell-enriched genes in the mouse embryo

    • Author(s)
      Takase H., Matsumoto K., Yamadera R., Kubota Y., Otsu A., Suzuki R., Ishitobi H., Mochizuki H., Kojima T., Takano S., Uchida K., Takahashi S., Ema M
    • Journal Title

      Blood

      Volume: 120 Pages: 914-923

    • Peer Reviewed
  • [Presentation] Origin of cardiovascular cells and heart development controlled by VEGF-Flk1 signaling2014

    • Author(s)
      Masatsugu Ema, Ayaka Otsu, Takuya Azami, Masanori Hirashima , Kazuko Koshiba-Takeuchi , Jun Takeuchi , Masabumi Shibuya, Janet Rossant, Satoru Takahashi, Tomomi Nishie
    • Organizer
      第91回生理学会大会, シンポジウム講演
    • Place of Presentation
      鹿児島
    • Year and Date
      20140000
  • [Presentation] VEGF-Flk1 による心臓発生のメカニズム2013

    • Author(s)
      西江 友美, 大津 彩香, 平島 正則, 小柴 和子, 竹内 純, 渋谷 正史, Janet Rossant, 高橋 智, 依 馬 正次 次
    • Organizer
      第36回分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      20130000
  • [Presentation] 心血管系細胞の起源と血管による心臓発生制御2013

    • Author(s)
      依馬 正次
    • Organizer
      第36回分子生物学会年会(ワークショップ)オーガナイザー
    • Place of Presentation
      神戸
    • Year and Date
      20130000
  • [Presentation] 血管内皮細胞関連遺伝子の網羅的探索による血管形成機序の解明2013

    • Author(s)
      依馬 正次
    • Organizer
      第21回日本血管生物医学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20130000
  • [Presentation] Genome-wide identification of angiogenesis- related genes in the mouse embryo2012

    • Author(s)
      Masatsugu Ema
    • Organizer
      第21回日本血管生物医学会学術集会
    • Place of Presentation
      徳島
    • Year and Date
      20120000
  • [Presentation] 新規血管内皮細胞特異的遺伝子群の網羅的探索2011

    • Author(s)
      松本 健, 高瀬 春華, 山寺 里枝, 大津 彩香, 石飛 博之, 小島 崇宏, 内田 和彦, 高橋 智, 依馬 正次
    • Organizer
      第34回分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      20110000
  • [Book] 発生期における血管形成制御因子の網羅的探索2013

    • Author(s)
      依馬 正次, 吉原 雅大
    • Publisher
      メディカルレビュー社

URL: 

Published: 2015-07-16  

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