2013 Fiscal Year Final Research Report
Establishing a new animal model for ankylosing spondylolysis using DCIR deficient mice
| Project/Area Number |
23500489
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Tokyo University of Science (2012-2013)
The University of Tokyo (2011) |
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Principal Investigator |
KAIFU Tomonori 東京理科大学, 生命医科学研究所, 助教 (90343037)
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| Co-Investigator(Kenkyū-buntansha) |
IWAKURA Yoichiro 東京理科大学, 生命医科学研究所, 教授 (10089120)
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| Project Period (FY) |
2011 – 2013
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| Keywords | C型レクチン受容体 / サイトカイン / 骨代謝 |
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| Research Abstract |
Ankylosing spondylolysis (AS) is one of typical diseases in spondyloarthlopathy, which develops ankylosis in joints, such as the spines and the sacroiliacs. Although enthesitis, an inflammation of the entheses, is known as a primitive symptom of ankylosisng spondylitis, the pathogenesis remains unclear and the curative treatment isn't yet determined. Since DCIR deficient mice spontaneously developed enthesitis and ankylosing in ankles, we exploited the DCIR deficient mice to understand the pathogenesis of an inflammation in the enthuses and a subsequent ankylosis as well as to generate a new animal mode for analyzing AS. We found that a pro-inflammtory cytokine was implicated in the development of ankylosis, which had the ability to facilitate bone formation. Therefore, this study demonstrates that the DCIR deficient mice are a useful animal model of AS to analyze the pathogenesis and to assess a potential reagent to cure the disease.
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[Presentation] DCIR 欠損マウスは強直性脊椎炎様の病態を示す2011
Author(s)
Maruhashi Takumi, Kaifu Tomonori, Ma guangyu, Seno Akimasa, Fujikado Noriyuki, Iwakura Yoichiro
Organizer
第40回日本免疫学会総会・学術集会
Place of Presentation
幕張
Year and Date
20111127-29
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[Presentation] DCIR リガンドの探索2011
Author(s)
矢部力朗, 丸橋拓海, 妹尾彬正, 馬光宇, 海部知則, 舘野浩章, 平林淳, 岩倉洋一郎
Organizer
第84回日本生化学会大会
Place of Presentation
京都
Year and Date
20110921-24
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