2013 Fiscal Year Final Research Report
Development of prediction and evaluation model of deformability of erythrocyte
| Project/Area Number |
23500532
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kansai University |
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Principal Investigator |
BANDO Kiyoshi 関西大学, システム理工学部, 教授 (70156545)
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| Co-Investigator(Renkei-kenkyūsha) |
OHBA Kenkichi 関西大学, システム理工学部, 教授 (30029186)
TAJIKAWA Tsutomu 関西大学, システム理工学部, 専任講師 (80351500)
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| Project Period (FY) |
2011 – 2013
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| Keywords | バイオメカニクス / 医用工学 / 赤血球 / マイクロカプセル / 変形能 / ＡＦＭ / マイクロマニピュレータ / 力学特性評価 |
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| Research Abstract |
Numerical simulations were performed corresponding to the following two experiments: an erythrocyte was passed through a micro-channel, and an erythrocyte was stretched uniaxially using micropipettes.As a result, it was shown that the evaluation of the change in the deformability of an erythrocyte is possible by examining the deformation behavior and that the deformability is influenced by the changes in the inner solution viscosity and the membrane Young's modulus of the erythrocyte. Microcapsule was produced as a model of in-vitro model of erythrocyte, and micro-plate compression experiment and indentation experiment using a sharp indenter were performed. It was shown that the mechanical properties, that is deformability, of a microcapsule are identified by fitting the force-displacement curves between the experiment and the deformation model calculation.
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