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2013 Fiscal Year Final Research Report

Surface modification of cardiovascular metal stents

Research Project

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Project/Area Number 23500540
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionTokyo Medical and Dental University

Principal Investigator

NAGAI Akiko  東京医科歯科大学, 生体材料工学研究所, 准教授 (40360599)

Co-Investigator(Kenkyū-buntansha) YAMASHITA Kimihiro  東京医科歯科大学, 生体材料工学研究所, 教授 (70174670)
NAKAMURA Miho  東京医科歯科大学, 生体材料工学研究所, 准教授 (40401385)
HORIUCHI Naohiro  東京医科歯科大学, 生体材料工学研究所, 助教 (90598195)
Project Period (FY) 2011 – 2013
Keywordsバイオマテリアル / 表面改変 / ステント材料 / 静電気力 / 血管内皮細胞 / 血小板
Research Abstract

We report on the surface modifications of metal substrates for stent, such as cobalt-chrome alloy and titanium alloy, for endothelialization at their surfaces by anodic oxidation treatment and femtosecond laser irradiation, respectively. We evaluated the surfaces using endothelial cells attachment test and platelet adhesion test in vitro. These results show their possibilities to be useful stent surfaces which promote attachments of endothelial cells for inhibiting restenosis and suppress adhesion of platelet inducing thrombogenesis.
Next, we investigated the mechanism of interactions between electrostatic force of the material surfaces and cell behaviors using an atomic force microscopy, a quartz crystal microbalance with dissipation monitoring, and a fluorescence microscope. The conformational changes of the serum protein modulate its configuration when adsorbed to the material surfaces and the initial cell behavior of cells on the surface with pre-adsorbed the protein.

  • Research Products

    (23 results)

All 2014 2013 2012 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 11 results) Presentation (6 results) Book (2 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Mouse embryonic stem cells cultured under serum- and feeder-free conditions maintain their self-renewal capacity on hydroxyapatite2014

    • Author(s)
      Nagai A, Hattori T, Hirose M, Ogura A, Nozaki K, Aizawa M, Yamashita K
    • Journal Title

      Mater Sci Engineer C

      Volume: 34 Pages: 214-220

    • DOI

      10.1016/j.msec.2013.09.012

    • Peer Reviewed
  • [Journal Article] Anodic oxidation of a Co-Ni-Cr-Mo alloy and its inhibitory effect on platelet activation2014

    • Author(s)
      Nagai A, Suzuki Y, Tsutsumi Y, Nozaki K, Wada N, Katayama K, Hanawa T, Yamashita K
    • Journal Title

      J Biomed Mater Res: Part B : Appl Biomater

      Volume: 102B Pages: 659-666

    • DOI

      10.1002/jbm.b.33044

    • Peer Reviewed
  • [Journal Article] Enhanced osteoinductivity of titanium implant by polarization-induced surface charges2014

    • Author(s)
      Nozaki K, Wang W, Horiuchi N, Nakamura M, Takakuda K, Yamashita K, Nagai A
    • Journal Title

      J Biomed Mater Res A

    • DOI

      10.1002/jbm.a.34980

    • Peer Reviewed
  • [Journal Article] Cell spreading on titanium dioxide film formed and modified with aerosol beam and femtosecond laser2014

    • Author(s)
      Shinonaga T, Tsukamoto M, Nagai A, Yamashita K, Hanawa T, Matsushita N, Xie G, Abe N
    • Journal Title

      Appl. Surf. Sci

      Volume: 288 Pages: 649-653

    • DOI

      10.1016/j.apsusc.2013.10.090

    • Peer Reviewed
  • [Journal Article] Dielectric properties of stoichiometric and defect-induced hydroxyapatite2013

    • Author(s)
      Horiuchi N, Endo J, Wada N, Nozaki K, Nakamura M, Nagai A, Katayama K, Yamashita K
    • Journal Title

      J. Appl. Phys

      Volume: 113 Pages: 134905

    • DOI

      10.1063/1.4799130

    • Peer Reviewed
  • [Journal Article] Characterization of bone mineral-resembling biomaterials for optimizing human osteoclast differentiation and resorption2013

    • Author(s)
      Nakamura M, Hentunen T, Salonen J, Nagai A, Yamashita K
    • Journal Title

      J Biomed Mater Res A

      Volume: 101A Pages: 3141-3151

    • DOI

      10.1002/jbm.a.34621

    • Peer Reviewed
  • [Journal Article] Quantitative evaluation of the hydrophilic properties of polarized hydroxyapatite2013

    • Author(s)
      Nagai A, Horiuchi N, Nozaki K, Nakamura M, Yamashita K
    • Journal Title

      Ceram Trans

      Volume: 242 Pages: 103-112

    • DOI

      10.1002/9781118751015.ch12

    • Peer Reviewed
  • [Journal Article] 高繰り返しナノ秒ファイバーレーザを用いたTi-6Al-4V 合金への微細周期構造形成2013

    • Author(s)
      谷川大地, 塚本雅裕, 篠永東吾, 永井亜希子, 塙 隆夫, 山下仁大, 升野振一郎, 高橋謙次郎, 藤崎 晃, 阿部信行
    • Journal Title

      レーザ加工学会誌

      Volume: 20 Pages: 124-129

    • URL

      http://ci.nii.ac.jp/naid/40019824582

    • Peer Reviewed
  • [Journal Article] Response of osteoblast-like MG63 cells to TiO2 layer prepared by micro-arc oxidized and electric polarization2012

    • Author(s)
      Nagai A, Yamazaki Y, Ma C, Nozaki K, Toyama T, Yamashita K
    • Journal Title

      J Euro Ceram Soc

      Volume: 32 Pages: 2647-2652

    • DOI

      10.1016/jeurceramsoc.2012.03.002

  • [Journal Article] Electrically polarized micro-arc oxidized TiO2 coatings with enhanced surface hydrophilicity2012

    • Author(s)
      Ma C, Nagai A, Yamazaki Y, Toyama T, Tsutsumi Y, Hanawa T, Wang W, Yamashita K
    • Journal Title

      Acta Biomater

      Volume: 6 Pages: 860-865

    • DOI

      10.1016/j.actbio.2011.09.021

    • Peer Reviewed
  • [Journal Article] Characterization of the air-formed surface oxide film on a Co-Ni-Cr-Mo alloy (MP35N) and its change in Hanks' solution2012

    • Author(s)
      Nagai A, Tsutsumi Y, Suzuki Y, Katayama K, Hanawa T, Yamashita K
    • Journal Title

      Appl. Surf. Sci

      Volume: 258 Pages: 5490-5498

    • DOI

      10.1016/j.apsusc.2012.02.057

    • Peer Reviewed
  • [Journal Article] Surface properties of Al2O3-YSZ ceramic composites modified by a combination of biomimetic coatings and electric polarization2012

    • Author(s)
      Nagai A, Ma C, Kishi S, Inuzuka M, Nakamura M, Horiuchi N, Nishio K, Yamashita K
    • Journal Title

      Appl Surf Sci

      Volume: 262 Pages: 45-50

    • DOI

      10.1016/j.apsusc.2012.01.038

    • Peer Reviewed
  • [Presentation] 生体活性チタニアエレクトレット2014

    • Author(s)
      永井亜希子, 他
    • Organizer
      日本金属学会2014年春期講演大会
    • Place of Presentation
      東京工業大学
    • Year and Date
      2014-03-22
  • [Presentation] Recent advances of carbonated apatite2013

    • Author(s)
      Nagai A, et al
    • Organizer
      2013 Asian Bioceramics Symposium
    • Place of Presentation
      京都大学
    • Year and Date
      2013-12-06
  • [Presentation] QCM-D assisted micro analysis of cell behaviors on hydroxyapatite films2013

    • Author(s)
      Matsui N, et al
    • Organizer
      2nd International Symposium on Inorganic and Environmental Materials
    • Place of Presentation
      Rennes, France
    • Year and Date
      2013-10-25
  • [Presentation] 陽極酸化によるCo-Cr合金の表面改質と生体適合性評価2012

    • Author(s)
      鈴木雄太, 他
    • Organizer
      日本バイオマテリアル学会シンポジウム2012
    • Place of Presentation
      東北大学
    • Year and Date
      2012-11-26
  • [Presentation] 分極炭酸アパタイト多孔体の作製2012

    • Author(s)
      永井亜希子, 他
    • Organizer
      日本セラミックス協会年会
    • Place of Presentation
      京都大学
    • Year and Date
      2012-03-20
  • [Presentation] Surface properties of electrically polarized Al2O3-YSZ ceramic composites2011

    • Author(s)
      Nagai A, et al
    • Organizer
      3rd International Symposium on Surface and Interface of Biomaterials
    • Place of Presentation
      北海道大学
    • Year and Date
      2011-07-01
  • [Book] 生体内埋め込み医療材料の開発とその理想的な性能・デザインの要件2013

    • Author(s)
      野崎浩佑, 山下仁大, 永井亜希子
    • Total Pages
      34-38
  • [Book] Biological interactions with surface charge biomaterials, RSC Nanoscience & Nanotechnology2012

    • Author(s)
      Horiuchi N, Nakamura M, Nagai A, Yamashita K
    • Total Pages
      262
    • Publisher
      Royal Society of Chemistry
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/i-mde/www/inorg/index.html

  • [Patent(Industrial Property Rights)] セラミックスの分極処理方法及び分極処理したセラミックスを含む生体材料2013

    • Inventor(s)
      山下仁大, 伊藤聡一郎, 永井亜希子
    • Industrial Property Rights Holder
      国立大学法人 東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      5414021
    • Acquisition Date
      2013-11-22
  • [Patent(Industrial Property Rights)] 金属酸化物, 金属材料, 生体親和材料, および金属酸化物の製造方法2011

    • Inventor(s)
      山下仁大, 永井亜希子, 馬楚凡
    • Industrial Property Rights Holder
      国立大学法人 東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      PCT/JP/2011/051672
    • Filing Date
      2011-05-11
    • Overseas

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Published: 2015-07-16  

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