Development of non-invasive protein drug delivery system across the blood-brain barrier

2013 Fiscal Year Final Research Report

• Project/Area Number: 23500547
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: KONDO Tetsuro 独立行政法人産業技術総合研究所, バイオメディカル研究部門, 主任研究員 (30344229)
• Project Period (FY): 2011 – 2013
• Keywords: 抗体医薬 / タンパク医薬 / 中枢神経系 / 血液脳関門 / 脳毛細血管内皮細胞 / アストロサイト / 指向性進化工学 / ファージディスプレイ

Outline of Final Research Achievements

We have developed new technologies of directed evolution to engineer functional peptide motifs that interact with membrane proteins expressed on the blood-brain barrier (BBB), aiming at establishing non-invasive protein drug delivery to the central nervous system. Using an in vitro BBB model, we performed repetitive selection and amplification of random peptide libraries and obtained peptide motif candidates that characteristically interact with the plasma membranes of brain-derived microvascular endothelial cells.

Free Research Field

総合領域