2013 Fiscal Year Final Research Report

Elucidation of role of climbing fibers in memory trace of motor learning.

Research Project

Project/Area Number	23500638
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Rehabilitation science/Welfare engineering
Research Institution	The Institute of Physical and Chemical Research
Principal Investigator	TATSUKAWA TETSUYA 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (60435659)
Project Period (FY)	2011 – 2013
Keywords	運動記憶 / 小脳核細胞 / シナプス可塑性
Research Abstract	Long-term depression (LTD) of synaptic efficacy at parallel fiber-Purkinje cell synapses and long-term potentiation (LTP) of synaptic efficacy at mossy fiber-deep cerebellar nuclei neuron synapses provide the underlying mechanisms for memory trace of motor learning. We analyzed intracellular signaling for the induction of LTP at mossy fiber-deep cerebellar nuclei synapses by means of whole-cell patch clamp technique in acute cerebellar slices of nitric oxide synthase knockout mice. We found that nitric oxide-protein kinase G signaling regulated the LTP induction by intracellular calcium level through hyperpolarization-activated cation currents.