2013 Fiscal Year Final Research Report
Influence of ribosome synthesis in muscle atrophy prevention mechanism by exercise
| Project/Area Number |
23500773
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Saga University (2013)
National Institute of Advanced Industrial Science and Technology (2012)
University of Tsukuba (2011) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKEMADSA Tohru 筑波大学, 体育系, 教授 (50236501)
KIYOSAWA Hidenori 高知大学, 医学部, 准教授 (30295422)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 骨格筋 / 筋萎縮 / リボソームRNA |
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| Research Abstract |
The main aim of the study was to elucidate the Influence of ribosome synthesis in muscle atrophy prevention mechanism by exercise. As a result we found that ribosomal RNA (rRNA) synthesis in skeletal muscle decreased in both common atrophy model as denervation and tail suspension. Additionally, in muscle recovery study, significantly high volume of total RNA was observed in plantaris muscle which had quickly recovered from atrophy. These results indicated that amount of rRNA synthesis is altered along change of skeletal muscle size. Furthermore, these results suggest the importance of rRNA in exercise-induced muscle atrophy prevention mechanism.
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