2013 Fiscal Year Final Research Report
Effects of aging and physical activity on regulation of ghrelin system
| Project/Area Number |
23500781
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | グレリン / 加齢 / 消化管ペプチド / 迷走神経 / 運動 |
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| Research Abstract |
Age-related declines of growth hormone secretion and food intake have been termed the somatopause and anorexia of aging, respectively. Ghrelin, a stomach-derived 28-amino-acid peptide, was isolated from human and rat stomachs as an endogenous ligand of growth hormone secretagogue receptor. Ghrelin stimulates growth hormone release and food intake when peripherally administered to rodents and humans. Therefore, aging process represented by catabolic-anabolic imbalance in peripheral tissues may increase ghrelin utilization to maintain cell functions, physical activity, and health. Unfortunately I could not identify the age-related decline of ghrelin synthesis in mice. Whereas I found relationship between plasma ghrelin level and incidence of cardiovascular disease. A maintenance of adequate ghrelin level seems to prevent the incidence of lifestyle related disease and to improve physical fitness for health.
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[Journal Article] Circulating Des-acyl Ghrelin Improves Cardiovascular Risk Prediction in Older Hypertensive Patients2014
Author(s)
Yano, Y., Nakazato, M., Toshinai, K., Inokuchi, T., Matsuda, S., Hidaka, T., Hayakawa, M., Kangawa, K., Shimada, K. and Kario, K
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Journal Title
Am J Hypertens
Volume: 27
Pages: 727-733
Peer Reviewed
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[Journal Article] Neuroendocrine regulatory peptide-1 and -2 (NERPs) inhibit the excitability of magnocellular neurosecretory cells in the hypothalamus2014
Author(s)
Toshinai, K., Saito, T., Yamaguchi, H., Sasaki, K., Tsuchimochi, W., Minamino, N., Ueta, Y. and Nakazato, M
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Journal Title
Brain Res
Volume: 1563
Pages: 52-60
Peer Reviewed
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[Journal Article] Ghrelin prevents the development of experimental diabetic neuropathy in rodents2013
Author(s)
Tsuchimochi, W., Kyoraku, I., Yamaguchi, H., Toshinai, K., Shiomi, K., Kangawa, K. and Nakazato, M
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Journal Title
Eur J Pharmacol
Volume: 702
Pages: 187-193
Peer Reviewed
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[Journal Article] Elevation of muscle temperature stimulates muscle glucose uptake in vivo and in vitro2013
Author(s)
Koshinaka, K., Kawamoto, E., Abe, N., Toshinai, K., Nakazato, M. and Kawanaka, K
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Journal Title
J Physiol Sci
Volume: 63
Pages: 409-418
Peer Reviewed
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[Journal Article] Neuroendocrine regulatory peptide-2 stimulates glucose-induced insulin secretion in vivo and in vitro2012
Author(s)
Moin, A. S., Yamaguchi, H., Rhee, M., Kim, J. W., Toshinai, K., Waise, T. M., Naznin, F., Matsuo, T., Sasaki, K., Minamino, N., Yoon, K. H. and Nakazato, M
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Journal Title
Biochem Biophys Res Commun
Volume: 428
Pages: 512-517
Peer Reviewed
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[Journal Article] Therapeutic potential of ghrelin treatment for unloading-induced muscle atrophy in mice2011
Author(s)
Koshinaka, K., Toshinai, K., Mohammad, A., Noma, K., Oshikawa, M., Ueno, H., Yamaguchi, H. and Nakazato, M
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Journal Title
Biochem Biophys Res Commun
Volume: 412
Pages: 296-301
Peer Reviewed
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[Journal Article] Significant lowering of plasma ghrelin but not des-acyl ghrelin in response to acute exercise in men2011
Author(s)
Shiiya, T., Ueno, H., Toshinai, K., Kawagoe, T., Naito, S., Tobina, T., Nishida, Y., Shindo, M., Kangawa, K., Tanaka, H. and Nakazato, M
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Journal Title
Endocr J
Volume: 58
Pages: 335-342
Peer Reviewed
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[Remarks] ホームページの開設準備中
