2013 Fiscal Year Final Research Report
Anti-lifestyle diseases effects of ghrelin with exercise therapy
| Project/Area Number |
23500782
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
UENO Hiroaki 宮崎大学, 医学部, 助教 (00381062)
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| Co-Investigator(Kenkyū-buntansha) |
TOSHINAI Koji 宮崎大学, 医学部内科学講座神経呼吸内分泌代謝学分野, 講師 (80381101)
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| Project Period (FY) |
2011 – 2013
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| Keywords | グレリン / 運動 / 成長ホルモン / 糖尿病 |
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| Research Abstract |
Plasma ghrelin level was significantly reduced by acute moderate exercise. In addition, plasma growth hormone (GH) and catecholamine levels were significantly increased during the exercise. Plasma ghrelin level was negatively correlated with plasma catecholamine level. Single administration of ghrelin to type 2 diabetic patients just before the test meal did not change the plasma glucose and insulin responses compared to control. Ghrelin 1.0 mmg/kg/day administration for 2-weeks increased plasma GH levels and did not change the body weight, plasma glucose and insulin levels in type 2 diabetic patients. Subjective symptoms of diabetic peripheral neuropathy and motor conduction velocity were significantly improved after 2-weeks administration of ghrelin. These results suggest that exogenous ghrelin administration, especially during exercise, increases plasma GH level additively without worsening glucose metabolism and ghrelin may have therapeutic potentials to diabetic polyneuropathy.
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[Journal Article] Significant lowering of plasma ghrelin but not des-acyl ghrelin in response to acute exercise in men2011
Author(s)
Shiiya T, Ueno H, Toshinai K, Kawagoe T, Naito S, Tobina T, Nishida Y, Shindo M, Kangawa K, Tanaka H, Nakazato M
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Journal Title
Endocr J
Volume: 58
Pages: 335-342
Peer Reviewed
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