Prolonged effect of carnitine administration on metabolism and central nervous system of fasted carnitine-deficient mice

2015 Fiscal Year Final Research Report

• Project/Area Number: 23500783
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: National Institute of Fitness and Sports in Kanoya
• Principal Investigator: YOSHIDA GOICHIRO 鹿屋体育大学, スポーツ生命科学系, 准教授 (10274870)
• Co-Investigator(Kenkyū-buntansha): SAHEKI Takeyori 鹿児島大学, 医歯学総合研究科, 研究員 (10056070) ; YOSHITAKE Yutaka 鹿屋体育大学, スポーツ人文・応用社会科学系, 教授 (00136334)
• Co-Investigator(Renkei-kenkyūsha): HORIUCHI Masahisa 鹿児島大学, 医歯学総合研究科, 教授 (50264403)
• Project Period (FY): 2011-04-28 – 2016-03-31
• Keywords: カルニチン / 脂肪酸酸化 / JVSマウス / 絶食 / オレキシン / 中枢神経系

Outline of Final Research Achievements

We examined the roles of carnitine in the general metabolism and the central nervous system, and the prolonged effects of carnitine administration to the fasted carnitine-deficient juvenile visceral steatosis (JVS) mice. Fasting reduced locomotor activity (LA) of JVS mice. Single carnitine administration caused an increase of the reduced LA and the fat expenditure, and the effects were prolonged for at least two days after the administration (as low as at the original carnitine-deficient state). In JVS mice, fasting also caused a decreased percentage of c-Fos positive orexin neurons in the lateral hypothalamus (ameliorated by carnitine administration). These results suggest that the reduced LA in fasted JVS mice is related to the inhibition of orexin neuronal activity.

Free Research Field

総合領域