Resistance training with blood flow restriction: from basic physiological study to creative clinical application

2013 Fiscal Year Final Research Report

• Project/Area Number: 23500784
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: Hokusho University
• Principal Investigator: OKITA KOICHI 北翔大学, 北翔大学, 教授 (80382539)
• Co-Investigator(Kenkyū-buntansha): KINUGAWA Shintaro 北海道大学医学研究科, 循環病態内科学, 講師 (60399871) ; YOKOTA Takashi 北海道大学医学研究科, 循環病態内科学, 助教 (90374321)
• Co-Investigator(Renkei-kenkyūsha): HORIUCHI Masahiro 山梨県環境科学研究所, 生理学研究室, 室長 (50310115) ; MORITA Noriteru 北海道教育大学, 教育学部, 准教授 (10382540)
• Project Period (FY): 2011 – 2013
• Keywords: 筋力トレーニング / エネルギー代謝 / 血流制限 / ミオカイン / BDNF

Research Abstract

We demonstrated that enhanced metabolic stress in exercising muscle is a key mechanism for favorable effects by resistance training and the elevated metabolic stress appears to be a crucial factor in obtaining successful results from resistance training (J Appl Physiol 2012). Based on these findings, we proposed the guidelines of resistance exercise with blood flow restriction for healthy subjects and diseased subjects such as diabetes and heart failure by considering individual characteristics, training status, disease status, age, and gender difference (Med Sci Sports Exerc 2012, Eur J Appl Physiol 2012, Jpn Coll Angiol 2012, Circ J 2013). Moreover, we applied this procedure to different types of athletes, sprinters and endurance runners, and also young athletes (Int J Vasc Med 2012, J Nov Physiother 2013).

Research Products

• [Journal Article] Application of Blood Flow Restriction in Resistance Exercise Assessed by Intramuscular Metabolic Stress (2013)
  • Author(s): Okita K, Takada S
  • Journal Title: J Nov Physiother Volume: 3:6 Pages: 87
  • DOI: 10.4172/2165-7025.1000187
  • Peer Reviewed
• [Journal Article] Resistance exercise with blood flow restriction in women (2013)
  • Author(s): Okita K, Takada S, Suga T, Kadoguchi T, Taniura T, Morita N, Yokota T, Kinugawa S, Tsutsui H
  • Journal Title: Proceeding of Asian Federation of Sports Medicine Volume: 1 Pages: 73-75
  • Peer Reviewed
• [Journal Article] Decreased serum brain-derived neurotrophic factor levels are correlated with exercise intolerance in patients with heart failure (2013)
  • Author(s): Fukushima A, Kinugawa S, Homma T, Masaki Y, Furihata T, Yokota T, Matsushima S, Abe T, Suga T, Takada S, Kadoguchi T, Katsuyama R, Oba K, Okita K, Tsutsui H
  • Journal Title: Int J Cardiol Volume: 168 Pages: e142-4
  • DOI: 10.1016/j.ijcard.2013.08.073
  • Peer Reviewed
• [Journal Article] Systemic Oxidative Stress Is Associated With Lower Aerobic Capacity and Impaired Skeletal Muscle Energy Metabolism in Patients With Metabolic Syndrome (2013)
  • Author(s): Yokota T, Kinugawa S, Yamato M, Hirabayashi K, Suga T, Takada S, Harada K, Morita N, Oyama-Manabe N, Kikuchi Y, Okita K, Tsutsui H
  • Journal Title: Diabetes Care Volume: 36 Pages: 1341-6
  • DOI: 10.2337/dc12-1161
  • Peer Reviewed
• [Journal Article] Exercise intolerance in chronic heart failure (2013)
  • Author(s): Okita K, Kinugawa S, Tsutsui H
  • Journal Title: Circ J Volume: 77 Pages: 293-300
  • Peer Reviewed
• [Journal Article] Blood flow restricted exercise and vascular function (2012)
  • Author(s): Horiuchi M, Okita K
  • Journal Title: Int J Vasc Med Pages: 543218
  • DOI: 10.1155/2012/543218
  • Peer Reviewed
• [Journal Article] Low-intensity exercise can increase muscle mass and strength proportionally to enhanced metabolic stress under ischemic conditions (2012)
  • Author(s): Takada S, Okita K, Suga T, Omokawa M, Kadoguchi T, Sato T, Takahashi M, Yokota T, Hirabayashi K, Morita N, Horiuchi M, Kinugawa S, Tsutsui H
  • Journal Title: J Appl Physiol Volume: 113 Pages: 199-205
  • Peer Reviewed
• [Journal Article] Blood Flow Restriction Exercise in Sprinters and Endurance Runners (2012)
  • Author(s): Takada S, Okita K, Suga T, Omokawa M, Morita N, Horiuchi M, Kadoguchi T, Takahashi M, Hirabayashi K, Yokota T, Kinugawa S, Tsutsui H
  • Journal Title: Med Sci Sports Exerc Volume: 44 Pages: 413-9
  • Peer Reviewed
• [Journal Article] Effect of multiple set on intramuscular metabolic stress during low-intensity resistance exercise with blood flow restriction (2012)
  • Author(s): Suga T, Okita K, Takada S, Omokawa M, Kadoguchi T, Yokota T, Hirabayashi K, Takahashi M, Morita N, Horiuchi M, Kinugawa S, Tsutsui H
  • Journal Title: Eur J Appl Physiol Volume: 108 Pages: 1563-7
  • Peer Reviewed
• [Journal Article] Combined Use of Near-infrared Spectroscopy with 31P-Magnetic Resonance Spectroscopy to Study Cardiovascular Pathophysiology (2012)
  • Author(s): Okita K
  • Journal Title: J Jpn Coll Angiol Volume: 52 Pages: 109-114
  • Peer Reviewed
• [Journal Article] Lower aerobic capacity was associated with abnormal intramuscular energetics in patients with metabolic syndrome (2011)
  • Author(s): Yokota T, Kinugawa S, Okita K, Hirabayashi K, Suga T, Hattori M, Nakagawa Y, Oyama-Manabe N, Shirato H, Tsutsui H
  • Journal Title: Hypertens Res Volume: 34 Pages: 1029-34
  • Peer Reviewed
• [Presentation] Decreased Serum Brain-Derived Neurotrophic Factor Levels are Associated with Exercise Intolerance in Patients with Heart Failure (2013)
  • Author(s): Takada S, Kinugawa S, Fukushima A, Homma T, Furihata T, Katsuyama R, Yokota T, Matsushima S, Abe T, Suga T, Kadoguchi T, Okita K, Tsutsui H
  • Organizer: 86th Scientific Session of American Heart Association
  • Place of Presentation: Dallas, USA
  • Year and Date: 20131116-20
• [Presentation] Resistance exercise with blood flow restriction in women (2013)
  • Author(s): Taniura T, Okita K, Takada S, Suga T, Kadoguchi T, Morita N, Kinugawa S, Tsutsui H
  • Organizer: 13th Asian Federation of Sports Medicine Congress
  • Place of Presentation: Kuala Lumpur, Malaysia
  • Year and Date: 20130925-28
• [Presentation] Effect of Blood Flow Restriction Timing in Enhancing Intramuscular Metabolic Stress During Resistance Exercise (2013)
  • Author(s): Okita K, Takada S, Suga T, Kadoguchi T, Sato T, Morita N, Taniura T, Horiuchi M, Kinugawa S, Tsuitsui H
  • Organizer: 18th annual congress of European college of sports science
  • Place of Presentation: Bacelona, Spain
  • Year and Date: 20130626-29
• [Presentation] Effect of music therapy on brain function as assessed by levels of brain-derived neurotrophic factor (2013)
  • Author(s): Taniura T, Okita K, Takada S, Sato T, Morita N, Sawada E
  • Organizer: 18th annual congress of European college of sports science
  • Place of Presentation: Bacelona, Spain
  • Year and Date: 20130626-29
• [Presentation] Evaluating the impact of blood flow restriction training on vascular function (2013)
  • Author(s): Horiuchi M, Sato T, Kadoguchi T, Okita K
  • Organizer: 18th annual congress of European college of sports science
  • Place of Presentation: Bacelona, Spain
  • Year and Date: 20130626-29
• [Presentation] BDNF-TrkB Pathway Plays an Important Role in the Effects of Exercise Training on Exercise Capacity and Skeletal Muscle Function in Mice. Circulation. 126: A14510 (2012)
  • Author(s): Takada S, Kinugawa S, Suga T, Fukushima A, Homma T, Masaki Y, Kadoguchi T, Furihata T, Okita K, Tsutsui H
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: Los Angeles, CA, USA
  • Year and Date: 20121103-07
• [Presentation] Effect of Exercise with Blood Flow Restriction Depends on Total Work Regardless of Mechanical Intensity (2012)
  • Author(s): Takada S, Okita K, Omokawa M, Suga T, Morita N, Horiuchi M, Kadoguchi T, Sato T, Takahashi M, Fukushima A, Honma T, Masaki Y, Kinugawa S, Tsutsui H
  • Organizer: ACSM 59th Annual Meeting and and World Congress on Exercise is Medicine
  • Place of Presentation: San Francisco, CA, USA
  • Year and Date: 20120529-0602