2013 Fiscal Year Final Research Report
Blunting of protein synthesis during exercise in rat skeletal muscle
| Project/Area Number |
23500789
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Shigakkan University |
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Principal Investigator |
MURAKAMI Taro 至学館大学, 健康科学部, 教授 (10252305)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIGURO Nahoko 至学館大学, 健康科学部, 助手 (10617260)
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| Project Period (FY) |
2011 – 2013
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| Keywords | たんぱく質合成 / mTORC1 / REDD1 / 4E-BP1 / SUnSET |
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| Research Abstract |
Protein synthesis is suppressed in working skeletal muscle. Teleologically, it makes sense that the muscle stops an ATP-consuming building process to spare ATP for contractile activity in an emergency. At least so far two mechanisms have been proposed for blunting protein synthesis in working muscle. One of them is a story that AMPK inhibits mTORC1, which is arguably a master regulator of initiation step in protein translation. Another story is that Ca2+-dependent inactivation of eEF2, which regulates elongation step in it. Reports in the literature suggest that other factors rather than AMPK and/or eEF2 would be involved in the blunting of protein synthesis. We have shown that REDD1 might be also a candidate for blunting protein synthesis in working muscle. Understanding of these mechanisms may lead to development of new strategies and treatments not only for athletes but also for individuals with muscle-wasting conditions such as sarcopenia.
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