Longitudinal study for the prevention of lifestyle-related diseases

2014 Fiscal Year Final Research Report

• Project/Area Number: 23500855
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Keio University
• Principal Investigator: HIROSE Hiroshi 慶應義塾大学, 保健管理センター, 准教授 (50208881)
• Co-Investigator(Kenkyū-buntansha): HOZAWA Shigenari 慶應義塾大学, 医学部, 講師 (40181482) ; SAITO Ikuo 慶應義塾大学, 保健管理センター, 教授 (60129442)
• Co-Investigator(Renkei-kenkyūsha): KAWABE Hiroshi 慶應義塾大学, 保健管理センター, 教授 (90129403)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: メタボリックシンドローム / アディポネクチン / 遺伝子多型

Outline of Final Research Achievements

In the 6-year longitudinal study on non-diabetic Japanese, aged 25-60 years, glucose tolerance had improved in only 2 subjects, was unchanged in 347 and worsened in 41 in males, and 0,133 and 14, respectively, in females.
Baseline factors correlating significantly with status [No change = 0/Worsened = 1] in males were age, BMI, plasma glucose, TG, LDL-cholesterol, ALT, γ-GTP, HOMA-R, high-molecular-weight (HMW)-adiponectin levels. No correlations were observed with baseline smoking, alcohol consumption or exercise status.
Stepwise multiple regression analysis of [No change/Worsened] as a dependent variable revealed that baseline glucose (F= 51.2, r’= 0.300), HMW-adiponectin (F = 11.5, r’= -0.165) and age (F = 5.1, r’= 0.110) to show significant independent correlations in males (P< 0.0001, R2= 0.156).

Free Research Field

スポーツ・健康科学