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2013 Fiscal Year Final Research Report

Induction of neurogenesis from endogenous neural precursors in the adult brain after stroke by long-term voluntary execise

Research Project

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Project/Area Number 23500866
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionKinki University

Principal Investigator

NIWA Atsuko  近畿大学, 医学部, 講師 (60122082)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Hideo  近畿大学, 医学部, 教授 (60335627)
Co-Investigator(Renkei-kenkyūsha) HAYASAKA Naoto  山口大学, 医学系研究科, 准教授 (80368290)
Project Period (FY) 2011 – 2013
Keywords脳血管障害 / 神経新生 / 血管新生 / 運動 / 神経幹細胞 / 骨髄細胞 / 再生環境 / 炎症
Research Abstract

Long-term voluntary exercise (EX) decreased stroke events in stroke-prone genetically hypertensive rats (SHRSP). Volume of cerebral lesion was also reduced and neural defects were improved, resulting in prolonged life span in post-stroke EX rats. Possible strategies for regenerating damaged central nervous system;(1)activation of endogenous neural stem (progenitor) cells (NSC) (2)modification of microenvironment surrounding stroke lesion for their development and differentiation (3)enhanced migration of endothelial progenitor cells (EPC) and NSC. We found that Ex increased the number of NSC and EPC, and enhaced their differentiation in lateral venticle and cerebral lesion. Cell senescence in bone marrow was suppressed by EX. Production of inflammatory factors in plasma, CSF and lesion was also decreased in EX rats. The improvement may depend on NO production. Nerve growth factors and chemokine including BDNF, FGF, EGF, IGF-1 and CXCL12 were produced in early phase after stroke in EX.

  • Research Products

    (4 results)

All 2014 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] In vivo diagnostic imaging using micro-CT : sequential and comparative evaluation of rodent models for hepatic/brain ischemia and stroke2012

    • Author(s)
      Hayasaka N, Nagai N, Kawao N, Niwa A, Yoshioka Y, Mori Y, Shigeta H, Kashiwagi N, Miyazawa M, Satou T, Higashino H, Matsuo O, Murakami T
    • Journal Title

      PLos One

      Volume: 7(2) Pages: e32342

    • DOI

      10.1371/journal.pone.0032342

    • Peer Reviewed
  • [Presentation] Voluntary exercise enhances neurogenesis in hypothalamus after stroke2014

    • Author(s)
      丹羽淳子
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Year and Date
      2014-03-21
  • [Presentation] Intervention with L-arginine promotes angiogenesis and neuroblast proliferation with stroke recovery2013

    • Author(s)
      丹羽淳子
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2013-03-23
  • [Presentation] Long-term voluntary exercise improves the efficacy of cerebral angiogenesis and neurogenesis in stroke-prone genetically hypertensive rats2012

    • Author(s)
      丹羽淳子
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-15

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Published: 2015-07-16  

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