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2013 Fiscal Year Final Research Report

Effects of menstrual cycle phase on exercise-induced whole body DNA damage and new insights into molecular mechanisms of breast cancer development

Research Project

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Project/Area Number 23500867
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionInternational Pacific University

Principal Investigator

YASUDA NOBUO  環太平洋大学, 体育学部, 准教授 (00467119)

Co-Investigator(Kenkyū-buntansha) TANIOKA Toshihiro  昭和大学, 薬学部, 助教 (80360585)
Project Period (FY) 2011 – 2013
Keywords応用健康科学 / 運動処方 / 運動療法 / 酸化ストレス
Research Abstract

The purpose of this study was to determine the effects of menstrual cycle phase on the relation between oxidative DNA damage and breast cancer following 2 h of prolonged cycling exercise in premenopausal women. Twelve recreationally active eumenorrheic women served as the subjects. Before and after 2 h of cycling exercise at 60%VO2peak, spot urine was collected for later analysis of urinary biomarkers. All subjects performed the same exercise protocol during the follicular and luteal phase. With regard to the levels of urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG, ng/mg creatinine) and ratio of estrogen metabolites (2-hydroxyestrone: 2-OHE1/16alpha-hydroxyestrone, 16alpha-OHE1), a two-way (time x phase) ANOVA showed no significant main effects or interaction. The findings of the present study indicate that the menstrual cycle phase appears not to influence oxidative DNA damage and incidence of breast cancer in premenopausal women following 2 h of acute bouts of moderate exercise.

  • Research Products

    (8 results)

All 2014 2013 2012

All Presentation (8 results)

  • [Presentation] The influence of two different menstrual cycle phases on the relationship between DNA oxidation and hydration status following exercise2014

    • Author(s)
      Yasuda N
    • Organizer
      Experimental Biology 2014
    • Place of Presentation
      San Diego, U.S.A
    • Year and Date
      20140400
  • [Presentation] Evaluation of menstrual cycle effects on mucosal immune function following intermittent exercise training, Journal of Science and Medicine in Sport2013

    • Author(s)
      Yasuda N, Tanioka T, Kanaura M, Adachi A
    • Organizer
      Asics Conference of Science and Medicine in Sport
    • Place of Presentation
      Phuket, Thailand
    • Year and Date
      20131000
  • [Presentation] Sex-based comparisons in oxidative DNA damage following 2h moderate cycling exercise2013

    • Author(s)
      Yasuda N, Tanioka T
    • Organizer
      Experimental Biology 2013
    • Place of Presentation
      Boston, U.S.A
    • Year and Date
      2013-04-09
  • [Presentation] Does 17beta-estradiol concentration influence on oxidative DNA damage following 2 hours of prolonged cycling exercise?2012

    • Author(s)
      Yasuda N, Tanioka T
    • Organizer
      The 85th Japanese Biochemical Society Annual Meeting
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      20121200
  • [Presentation] Sex-based differences in salivary α -amylase activity following maximal cycling exercise. Journal of Science and Medicine in Sport2012

    • Author(s)
      Yamamoto K, Iwashita N, Tanioka T, Yasuda N
    • Organizer
      Be Active 2012 : Australian Conference of Science and Medicine in Sport
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      20121100
  • [Presentation] Effects of menstrual cycle phase on salivary α-amylase activity following 2 hours of cycling exercise in recreationally active eumenorrheic women. Journal of Science and Medicine in Sport2012

    • Author(s)
      Yasuda N, Tanioka T, Iwashita N, Yamamoto K
    • Organizer
      Be Active 2012 : Australian Conference of Science and Medicine in Sport
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      20121100
  • [Presentation] Sex-based differences in salivary α-amylase and IgA responses following submaximal cycling exercise. The Physiologist2012

    • Author(s)
      Teraoka R, Tanioka T, Yasuda N
    • Organizer
      The 12th Integrative Biology of Exercise Conference
    • Place of Presentation
      Colorado, USA
    • Year and Date
      20121000
  • [Presentation] Effects of the menstrual cycle phase on oxidative DNA damage following submaximal cycling exercise. The Physiologist2012

    • Author(s)
      Yasuda N, Tanioka T
    • Organizer
      The 12th Integrative Biology of Exercise Conference
    • Place of Presentation
      Colorado, USA
    • Year and Date
      20121000

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Published: 2015-07-16  

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