2013 Fiscal Year Final Research Report
Study on the relation of folate intake and lipid metabolism
| Project/Area Number |
23500954
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Nara Women's University |
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Principal Investigator |
NAKATA Rieko 奈良女子大学, 生活環境科学系, 講師 (90198119)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 葉酸 / 脂質代謝 / 高脂肪食 / コリン |
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| Research Abstract |
In this study, we investigated the effect of folate and choline deficiency on lipid metabolism in high fat intake. Folate deficiency induced increase of liver weight, and decrease of white adipose weights. Triglyceride and lipid droplets were accumulated in liver by folate and choline deficiency. Moreover, folate and choline deficiency caused impairment of fatty acid synthesis, oxidation and transport, and decrease of triglyceride concentration in VLDL. These results suggest that folate deficiency affect on lipid metabolism in liver, and that the influence aggravate it more by folate and choline deficiency,
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